7464-09-7

Basic information

• Product Name: thiazolo[4,5-d]pyriMidine-5,7-diol
• Synonyms: thiazolo[4,5-d]pyriMidine-5,7-diol;Thiazolo[4,5-d]pyrimidine-5,7(4H,6H)-dione
• CAS NO: 7464-09-7
• Molecular Formula: C5H3N3O2S
• Molecular Weight: 169.16122
• Mol File: 7464-09-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 305-310 °C (decomp)(Solv: chloroform (67-66-3))
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.626g/cm³
• Refractive Index: 1.635
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.82±0.20(Predicted)
• CAS DataBase Reference: thiazolo[4,5-d]pyriMidine-5,7-diol(CAS DataBase Reference)
• NIST Chemistry Reference: thiazolo[4,5-d]pyriMidine-5,7-diol(7464-09-7)
• EPA Substance Registry System: thiazolo[4,5-d]pyriMidine-5,7-diol(7464-09-7)

Safety Data

• Hazardous Substances Data: 7464-09-7(Hazardous Substances Data)

Usage

General Description

Thiazolo[4,5-d]pyrimidine-5,7-diol is a chemical compound with a fused heterocyclic ring structure that contains nitrogen and sulfur atoms. It is a type of pyrimidine derivative, which is a class of organic compounds that are commonly found in nucleic acids and have various biological activities. Thiazolo[4,5-d]pyrimidine-5,7-diol has been studied for its potential use in medicinal chemistry, particularly in the development of new drugs for diseases such as cancer, inflammation, and neurodegenerative disorders. Its unique structure and properties make it an interesting target for further research in the field of drug discovery and development.

InChI:InChI=1/C5H3N3O2S/c9-4-2-3(6-1-11-2)7-5(10)8-4/h1H,(H2,7,8,9,10)

Upstream product

• 7464-10-0 thiazole-4,5-dicarboxylic acid diamide 
• 57-13-6 urea 
• 278183-10-1 methyl 4-amino-1,3-thiazole-5-carboxylatte 
• 30161-92-3 2-chloro-4H-thiazolo[4,5-d]pyrimidine-5,7-dione 
• 23126-24-1 6-amino-5-thiocyanato-1H-pyrimidine-2,4-dione 
• 30161-91-2 2-amino-4H-thiazolo[4,5-d]pyrimidine-5,7-dione 

Downstream Products

• 28969-60-0 4-amino-2,5,6-trichloropyrimidine 

Relevant articles and documents

Preparation method of 5-bromine-thiazolo [4,5-D] pyrimidine

The invention discloses a preparation method of 5-bromine-thiazolo [4,5-D] pyrimidine. The preparation method comprises the following specific steps of by adopting 4-amino-5-thiazolecarboxylate as an initial material, preparing thiazolo [4,5-D] pyrimidine-5,7-glycol through cyclization; preparing thiazolo [4,5-D] pyrimidine-5,7-dibromo from the thiazolo [4,5-D] pyrimidine-5,7-glycol through bromination reaction; and finally preparing 5-bromine-thiazolo [4,5-D] pyrimidine from the thiazolo [4,5-D] pyrimidine-5,7-dibromo through hydrogenation. The method is short in process route, convenient to operate, relatively mild in reaction condition, easy to control, relatively low in cost and suitable for process amplification, and a product is easy to purify and relatively high in yield.

THIAZOLOPYRIMIDINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE

Compounds of Formulas (Ia and Ib), and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of formula Ia and Ib for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed