7464-20-2

Basic information

• Product Name: 2-Benzothiazolamine,6-chloro-N,N-dimethyl-(9CI)
• Synonyms: 2-Benzothiazolamine,6-chloro-N,N-dimethyl-(9CI)
• CAS NO: 7464-20-2
• Molecular Formula: C9H9ClN2S
• Molecular Weight: 212.69916
• Product Categories: BENZOTHIAZOLE
• Mol File: 7464-20-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 301.5 °C at 760 mmHg
• Flash Point: 136.2 °C
• Appearance: /
• Density: 1.361 g/cm³
• Vapor Pressure: 0.00105mmHg at 25°C
• Refractive Index: 1.691
• CAS DataBase Reference: 2-Benzothiazolamine,6-chloro-N,N-dimethyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Benzothiazolamine,6-chloro-N,N-dimethyl-(9CI)(7464-20-2)
• EPA Substance Registry System: 2-Benzothiazolamine,6-chloro-N,N-dimethyl-(9CI)(7464-20-2)

Safety Data

• Hazardous Substances Data: 7464-20-2(Hazardous Substances Data)

Usage

General Description

2-Benzothiazolamine, 6-chloro-N,N-dimethyl-(9CI) is a chemical compound that belongs to the class of benzothiazole derivatives. It is a yellow to brown solid that is insoluble in water but soluble in organic solvents. This chemical is known for its potential application as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It also possesses biological activity and has been studied for its potential use as a therapeutic agent. Additionally, it has been investigated for its role in materials science, particularly in the development of various types of polymers and other materials. Overall, 2-Benzothiazolamine, 6-chloro-N,N-dimethyl-(9CI) is a versatile compound with various potential uses in both the pharmaceutical and materials industries.

InChI:InChI=1/C9H9ClN2S/c1-12(2)9-11-7-4-3-6(10)5-8(7)13-9/h3-5H,1-2H3

Upstream product

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Relevant articles and documents

A Mild Synthesis of 2-Substituted Benzothiazoles via Nickel-Catalyzed Intramolecular Oxidative C-H Functionalization

A highly efficient synthetic method for the preparation of 2-aminobenzothiazoles starting from arylthioureas has been reported. By using a nickel catalyst, arylthioureas undergo intramolecular oxidative C-H bond functionalization, giving the desired 2-aminobenzothiazoles in good to excellent yields. This protocol features an inexpensive catalyst, low catalyst loading, mild reaction conditions, a short reaction time, and good to excellent yields, and it can be scaled up easily to a gram scale with almost no yields decreasing.

Method for catalytically synthesizing 2-aminobenzothiazole derivative by N, N-dimethylthio carbamoyl chloride under microwave radiation

The invention discloses a method for catalytically synthesizing a 2-aminobenzothiazole derivative under microwave radiation. A catalytic amount of copper iodide serving as a catalyst, 8-hydroxyquinoline serving as a ligand, potassium hydroxide serving as an auxiliary catalyst, 2-halogenated aniline, a derivative of 2-halogenated aniline, powdered sulfur, an N, N-dimethylthio carbamoyl chloride derivative and pyridine are added into a reaction vessel, the reaction vessel is placed into a microwave reactor, reaction is performed at a certain temperature and under a certain power, vacuum concentration is performed after a certain time, and a product is purified by column chromatography. According to the method, raw materials are novel, operation is simple and convenient, and the 2-aminobenzothiazole derivative is efficiently prepared. Compared with the prior art, the method has the advantages that reaction speed is obviously increased as compared with conventional heating, reaction conditions are mild, and the method is simple in operation, high in yield, safe, low in cost and environmentally friendly.

Metal-free or transition-metal-catalyzed one-pot synthesis of 2-aminobenzothiazoles

A series of 2-aminobenzothiazoles were synthesized by using 2-halogen-substituted anilines (halogen = Cl, Br, I) and dithiocarbamates in the presence of KOt-Bu. This simple and efficient protocol lets the reactions undergo in a smooth and rapid way to afford the corresponding 2-aminobenzothiazoles in good yields. It is noteworthy that the present process allows the construction of 2-aminobenzothiazoles from a wide range of 2-halogen-substituted aniline derivatives, including substituted 2-iodoanilines, 2-bromoanilines and 2-chloroanilines.