7464-55-3

Basic information

• Product Name: 4-METHOXY-N-(2-METHOXYPHENYL)BENZAMIDE
• Synonyms: 4-METHOXY-N-(2-METHOXYPHENYL)BENZAMIDE
• CAS NO: 7464-55-3
• Molecular Formula: C₁₅H₁₅NO₃
• Molecular Weight: 257.2845
• Mol File: 7464-55-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 338.2°Cat760mmHg
• Flash Point: 158.4°C
• Appearance: /
• Density: 1.189g/cm³
• Vapor Pressure: 9.95E-05mmHg at 25°C
• Refractive Index: 1.601
• CAS DataBase Reference: 4-METHOXY-N-(2-METHOXYPHENYL)BENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXY-N-(2-METHOXYPHENYL)BENZAMIDE(7464-55-3)
• EPA Substance Registry System: 4-METHOXY-N-(2-METHOXYPHENYL)BENZAMIDE(7464-55-3)

Safety Data

• Hazardous Substances Data: 7464-55-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H15NO3/c1-18-12-9-7-11(8-10-12)15(17)16-13-5-3-4-6-14(13)19-2/h3-10H,1-2H3,(H,16,17)

Upstream product

• 90-04-0 2-methoxy-phenylamine 
• 100-07-2 4-methoxy-benzoyl chloride 
• 201230-82-2 carbon monoxide 
• 5720-07-0 4-methoxyphenylboronic acid 
• 492-95-5 2-methoxyphenyldiazonium tetrafluoroborate 
• 529-28-2 4-iodoanisol 
• 2393-23-9 4-methoxy-benzylamine 
• 100-09-4 4-methoxybenzoic acid 
• 1402345-49-6 N,4-dimethoxy-N-phenylbenzamide 

Downstream Products

• 174412-29-4 4-hydroxy-N-(2-hydroxyphenyl)benzamide 
• 3315-19-3 2-(4-hydroxyphenyl)benzoxazole 

Relevant articles and documents

Cationic N-Heterocyclic Carbene Copper-Catalyzed [1,3]-Alkoxy Rearrangement of N-Alkoxyanilines

The [1,3]-alkoxy rearrangement reactions of N-alkoxyanilines were efficiently catalyzed by cationic N-heterocyclic carbene (NHC)-Cu catalysts in affording 2-alkoxyaniline derivatives in good to excellent yields with high functional group compatibility. For N-alkoxyanilines having an electron-withdrawing substituent at the meta-position, the alkoxy group selectively migrated to the more hindered ortho-position. In contrast, the alkoxy group migrated to the less hindered ortho-position for N-alkoxyanilines having an electron-donating substituent. Mechanistic studies suggest that the rearrangement reactions proceed via an intramolecular route.

The synthesis of N-arylated amides via copper(II) triflate-catalyzed direct oxygenation and N-arylation of benzylamines with aryl iodides

An efficient approach for the synthesis of N-arylated amides by copper(II) triflate-catalyzed direct oxygenation and N-arylation reaction of benzylamines with aryl iodides is reported. Various benzylamines and aryl iodides can participate in the reaction, providing a series of N-arylated amides in moderate to good yields.

Palladium-Imidazolium N-Heterocyclic Carbene-Catalyzed Carbonylative Amidation with Boronic Acids, Aryl Diazonium Ions, and Ammonia

Aryl diazonium tetrafluoroborates have been coupled with arylboron compounds, carbon monoxide, and ammonia to give aryl amides in high yields. A saturated N-heterocyclic carbene (NHC) ligand, H2IPr was used with palladium(II) acetate to give the active catalyst. A mechanism is proposed for this novel four-component coupling reaction.