7465-32-9Relevant articles and documents
C?H Insertion as a Key Step to Spiro-Oxetanes, Scaffolds for Drug Discovery
Nicolle, Simon M.,Nortcliffe, Andrew,Bartrum, Hannah E.,Lewis, William,Hayes, Christopher J.,Moody, Christopher J.
, p. 13623 - 13627 (2017/09/13)
A new route to spiro-oxetanes, potential scaffolds for drug discovery, is described. The route is based on the selective 1,4-C?H insertion reactions of metallocarbenes, generated from simple carbonyl precursors in flow or batch mode, to give spiro-β-lacto
AN EFFICIENT, HIGHLY REGIOSELECTIVE SYNTHESIS OF SUBSTITUTED (1-CYCLOHEXENYL) ACETIC ACID DERIVATIVES VIA IONIZATION/ELIMINATION OF β-LACTONES
Black, T. Howard,Maluleka, Stephen L.
, p. 531 - 534 (2007/10/02)
When treated with magnesium bromide, spiro β-lactones undergo an ionization/elimination reaction to afford cyclohexenyl acetic acid derivatives in high yield and isomeric purity.