7465-48-7

Basic information

• Product Name: 5,6,7,8-Tetrahydrotetrazolo[1,5-a]pyridine
• Synonyms: 5,6,7,8-Tetrahydrotetrazolo[1,5-a]pyridine;Tetramethylenetetrazole
• CAS NO: 7465-48-7
• Molecular Formula: C₅H₈N₄
• Molecular Weight: 124.1438
• Mol File: 7465-48-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 336°Cat760mmHg
• Flash Point: 157°C
• Appearance: /
• Density: 1.53g/cm³
• Vapor Pressure: 0.000115mmHg at 25°C
• Refractive Index: 1.772
• CAS DataBase Reference: 5,6,7,8-Tetrahydrotetrazolo[1,5-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6,7,8-Tetrahydrotetrazolo[1,5-a]pyridine(7465-48-7)
• EPA Substance Registry System: 5,6,7,8-Tetrahydrotetrazolo[1,5-a]pyridine(7465-48-7)

Safety Data

• Hazardous Substances Data: 7465-48-7(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthesis, p. 1218, 1993 DOI: 10.1055/s-1993-26027

InChI:InChI=1/C5H8N4/c1-2-4-9-5(3-1)6-7-8-9/h1-4H2

Upstream product

• 274-87-3 tetrazolo[1,5-a]pyridine 
• 21994-41-2 5-azidopentanenitrile 
• 120-92-3 cyclopentanone 
• 660-88-8 5-aminopentanoic acid 

Downstream Products

• 32847-45-3 N-(but-3-en-1-yl)cyanamide 
• 926290-89-3 acetic acid phenyl-(5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyridin-8-yl)-methyl ester 
• 954154-12-2 8-benzylidene-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyridine 

Relevant articles and documents

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Convergent Three-Component Tetrazole Synthesis

A microwave-accelerated, simple, and efficient method for the construction of the 1,5-tetrazole scaffold was developed. It comprises a multicomponent reaction of an amine, a carboxylic acid derivative, and an azide source. On the basis of the availability of the archetypical starting materials, this method provided very versatile synthetic access to 1,5-disubstituted tetrazoles. The usefulness of this method was demonstrated in the synthesis of biologically important fused tetrazole scaffolds and the marketed drug cilostazol.

Preparation of 1,5-fused tetrazoles under solvent-free conditions

A facile and efficient procedure is developed for a one-pot synthesis of fused 1,5-disubstituted tetrazoles from cyclic ketones and sodium azide in the presence of aluminum chloride in solvent-free media. Advantages of this method are chemoselectivity, with high yields in a simple operation, and short reaction time under solvent-free conditions. Copyright Taylor & Francis, Inc.