7465-63-6

Basic information

• Product Name: 2-(4-nitrophenyl)-4,5-dihydro-1,3-oxazole
• Synonyms: oxazole, 4,5-dihydro-2-(4-nitrophenyl)-
• CAS NO: 7465-63-6
• Molecular Formula: C₉H₈N₂O₃
• Molecular Weight: 192.1714
• Mol File: 7465-63-6.mol
• Article Data: 31

Chemical Properties

• Boiling Point: 350.7°C at 760 mmHg
• Flash Point: 165.9°C
• Density: 1.4g/cm³
• Vapor Pressure: 8.72E-05mmHg at 25°C
• Refractive Index: 1.634
• CAS DataBase Reference: 2-(4-nitrophenyl)-4,5-dihydro-1,3-oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-nitrophenyl)-4,5-dihydro-1,3-oxazole(7465-63-6)
• EPA Substance Registry System: 2-(4-nitrophenyl)-4,5-dihydro-1,3-oxazole(7465-63-6)

Safety Data

• Hazardous Substances Data: 7465-63-6(Hazardous Substances Data)

Usage

Heterocyclic compound

Contains a five-membered ring with oxygen and nitrogen atoms
A compound with a ring structure that includes at least one oxygen or nitrogen atom in the ring, differentiating it from purely carbon-based rings.

Presence of a nitrophenyl group

Gives the compound a yellow color
A functional group consisting of a nitro group (-NO2) attached to a phenyl ring (a six-membered carbon ring) that imparts a distinct yellow color to the compound.
4. Applications in organic synthesis and pharmaceutical research
The compound serves as a valuable building block for the synthesis of various organic compounds and has potential pharmacological activities, making it useful in the development of new drugs.

Unique structure and properties

Contribute to its value in chemical synthesis and drug development
The specific arrangement of atoms and the presence of different functional groups in the molecule contribute to its distinct properties, making it an important compound for further research and development in the fields of organic synthesis and pharmaceuticals.

Upstream product

• 19614-29-0 1-(p-nitrobenzoyl)aziridine 
• 333-20-0 potassium thioacyanate 
• 67-64-1 acetone 
• 108481-60-3 4-nitro-benzoic acid-(2-bromo-ethylamide) 
• 124-41-4 sodium methylate 
• 51816-15-0 N-(2-chloroethyl)-4-nitrobenzamide 
• 126121-23-1 1-nitroso-2-phenyl-4,5-dihydro-1H-imidazole 
• 6640-65-9 N-(2-hydroxyethyl)-4-nitrobenzamide 
• 126121-25-3 2-(4-Nitro-phenyl)-1-nitroso-4,5-dihydro-1H-imidazole 
• 75-05-8 acetonitrile 
• 555-16-8 4-nitrobenzaldehdye 
• 141-43-5 ethanolamine 
• 619-73-8 4-nitrobenzyl chloride 
• 62-23-7 4-nitro-benzoic acid 

Downstream Products

• 37056-16-9 N-(2-chloro-ethyl)-4-nitro-dibenzamide 
• 23990-56-9 7a-(4-nitro-phenyl)-7,7-dioxo-tetrahydro-7λ⁶-thiazolo[2,3-b]oxazol-5-one 
• 62882-08-0 2-(p-Nitrophenyl)oxazole 
• 81592-51-0 Trifluoro-methanesulfonate3-methyl-2-(4-nitro-phenyl)-4,5-dihydro-oxazol-3-ium; 
• 90776-77-5 4-Methyl-5-(4-nitro-phenyl)-7-oxo-2,3,4,7-tetrahydro-[1,4]oxazepine-6-carbonitrile 
• 1322669-51-1 C₁₈H₁₄ClN₃O 

Relevant articles and documents

Insights into the antiproliferative mechanism of (C^N)-chelated half-sandwich iridium complexes

Transition metal-based anticancer compounds, as an alternative to platinum derivatives, are raising scientific interest as they may present distinct although poorly understood mechanisms of action. We used a structure-activity relationship-based methodology to investigate the chemical and biological features of a series of ten (C^N)-chelated half-sandwich iridiumIII complexes of the general formula [IrCp?(phox)Cl], where (phox) is a 2-phenyloxazoline ligand forming a 5-membered metallacycle. This series of compounds undergoes a fast exchange of their chlorido ligand once solubilised in DMSO. They were cytotoxic to HeLa cells with IC50 values in the micromolar range and induced a rapid activation of caspase-3, an apoptosis marker. In vitro, the oxidative power of all the complexes towards NADH was highlighted but only the complexes bearing substituents on the oxazoline ring were able to produce H2O2 at the micromolar range. However, we demonstrated using a powerful HyPer protein redox sensor-based flow cytometry assay that most complexes rapidly raised intracellular levels of H2O2. Hence, this study shows that oxidative stress can partly explain the cytotoxicity of these complexes on the HeLa cell line and gives a first entry to their mechanism of action. This journal is

A 2 - substituted oxazoline or 2 - substituted piperazine synthetic method (by machine translation)

The invention discloses a method for synthesizing 2 - substituted oxazoline or 2 - substituted oxazine new method, by nitrile and amino ethanol or 3 - amino - 1 - propanol as raw material, in the absence of solvent, can be used for the recycling of the sulfur to induce synthesis of 2 - substituted oxazoline and 2 - substituted piperazine. The method of the invention has low cost, simple reaction process, mild reaction conditions, the reaction time is short, the yield and the like, is suitable for the industrial generation. (by machine translation)

Microwave-Assisted Synthesis of 2-Aryl-2-oxazolines, 5,6-Dihydro-4H-1,3-oxazines, and 4,5,6,7-Tetrahydro-1,3-oxazepines

The first general procedure for the synthesis of 5- to 7-membered cyclic iminoethers by microwave-assisted cyclization of ω-amido alcohols promoted by polyphosphoric acid (PPA) esters is presented. 2-Aryl-2-oxazolines and 5,6-dihydro-4H-1,3-oxazines were efficiently prepared using ethyl polyphosphate/CHCl3. Trimethylsilyl polyphosphate in solvent-free conditions allowed for the synthesis of hitherto-unreported 4,5,6,7-tetrahydro-1,3-oxazepines. The method involves good to excellent yields and short reaction times.The reaction mechanism and the role of PPA esters were investigated in a chiral substrate.