746666-66-0Relevant articles and documents
γ-Lactams as glycinamide replacements in cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists
Cherney, Robert J.,Mo, Ruowei,Meyer, Dayton T.,Voss, Matthew E.,Yang, Michael G.,Santella III, Joseph B.,Duncia, John V.,Lo, Yvonne C.,Yang, Gengjie,Miller, Persymphonie B.,Scherle, Peggy A.,Zhao, Qihong,Mandlekar, Sandhya,Cvijic, Mary Ellen,Barrish, Joel C.,Decicco, Carl P.,Carter, Percy H.
scheme or table, p. 2425 - 2430 (2010/08/05)
We describe the design, synthesis, and evaluation, of γ-lactams as glycinamide replacements within a series of di- and trisubstituted cyclohexane CCR2 antagonists. The lactam-containing trisubstituted cyclohexanes proved to be more potent than the disubst
