746668-78-0

Basic information

• Product Name: 1H-Pyrazole-1-sulfonaMide, 4-iodo-N,N-diMethyl-3-(2-pyridinyl)-
• Synonyms: 1H-Pyrazole-1-sulfonaMide, 4-iodo-N,N-diMethyl-3-(2-pyridinyl)-;4-Iodo-N,N-dimethyl-3-(pyridin-2-yl)-1H-pyrazole-1-sulfonamide
• CAS NO: 746668-78-0
• Molecular Formula: C₁₀H₁₁IN₄O₂S
• Molecular Weight: 378.18941
• Mol File: 746668-78-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1H-Pyrazole-1-sulfonaMide, 4-iodo-N,N-diMethyl-3-(2-pyridinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-1-sulfonaMide, 4-iodo-N,N-diMethyl-3-(2-pyridinyl)-(746668-78-0)
• EPA Substance Registry System: 1H-Pyrazole-1-sulfonaMide, 4-iodo-N,N-diMethyl-3-(2-pyridinyl)-(746668-78-0)

Safety Data

• Hazardous Substances Data: 746668-78-0(Hazardous Substances Data)

Usage

Chemical Class

1H-Pyrazole-1-sulfonamide

Substitution

4-iodo-N,N-dimethyl-3-(2-pyridinyl)

Type

Organic compound

Molecular weight

363.20 g/mol

Functional groups

Sulfonamide and pyridinyl group

Use in synthesis

Used in the synthesis of various pharmaceuticals and agrochemicals

Biological activity

Inhibits the enzyme phosphodiesterase 5 (PDE5)

Potential applications

Treatment of erectile dysfunction and antimicrobial agent against bacteria and fungi

Ongoing research

Precise applications and uses are subject to ongoing research and development in the pharmaceutical and agricultural industries.

Upstream product

• 746668-75-7 2-(4-iodo-1H-pyrazol-3-yl)-pyridine 
• 13360-57-1 dimethylamino sulfonyl chloride 

Downstream Products

• 746668-84-8 2-(1-dimethylsulfamoyl-3-pyridin-2-yl-1H-pyrazole-4-carbonyl)-benzoic acid 

Relevant articles and documents

PYRAZOLES AND METHODS OF MAKING AND USING THE SAME

The invention is based on the discovery that compounds of formula I possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. In one embodiment, the invention features a compound of formula I (I).