74669-41-3

Basic information

• Product Name: 4(1H)-Pyridinone, 1-(phenylacetyl)-
• CAS NO: 74669-41-3
• Molecular Formula: C13H11NO2
• Molecular Weight: 213.236
• Mol File: 74669-41-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4(1H)-Pyridinone, 1-(phenylacetyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Pyridinone, 1-(phenylacetyl)-(74669-41-3)
• EPA Substance Registry System: 4(1H)-Pyridinone, 1-(phenylacetyl)-(74669-41-3)

Safety Data

• Hazardous Substances Data: 74669-41-3(Hazardous Substances Data)

Upstream product

• 108-96-3 4-pyridone 
• 103-82-2 phenylacetic acid 

Relevant articles and documents

Acylation of 4-Pyridone

Only N-acyl-4-pyridones (5) are isolable from the acylation of 4-pyridone (1) with aliphatic carboxylic anhydrides, and chlorides or free acids in the presence of dicyclohexylcarbodiimide.Similarly the reaction of 1with ortho substituted derivatives of benzoic acid leads only to N-acylation products 8, while benzoyl chloride as well as benzoic acid derivatives 7i-s (meta or para substituted), 3,5-dinitrobenzoyl chloride, and the 2,4-dimethyl substituted benzoyl chlorides 7v-z give exclusively 4-(acyloxy)pyridines 9.Reaction of phthaloyl chloride (10) with 1 yields both N- and O-acylation products.In solution even at room temperature the N-acylation compounds 2 and 8 are in equilibrium with the (acyloxy)pyridines 3 and 9, respectively.The position of the equilibrium depends mainly on the structure of the acyl residue, it is, however, also effected by temperature and polarity of the solvent.