7470-50-0

Basic information

• Product Name: N-(3-nitrophenyl)propionamide
• Synonyms: N-(3-nitrophenyl)propionamide
• CAS NO: 7470-50-0
• Molecular Formula: C₉H₁₀N₂O₃
• Molecular Weight: 194.1873
• EINECS: 231-267-3
• Mol File: 7470-50-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 104-104.5 °C
• Boiling Point: 384.9°C at 760 mmHg
• Flash Point: 186.6°C
• Appearance: /
• Density: 1.287g/cm³
• Vapor Pressure: 3.96E-06mmHg at 25°C
• Refractive Index: 1.601
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.20±0.70(Predicted)
• CAS DataBase Reference: N-(3-nitrophenyl)propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-nitrophenyl)propionamide(7470-50-0)
• EPA Substance Registry System: N-(3-nitrophenyl)propionamide(7470-50-0)

Safety Data

• Hazardous Substances Data: 7470-50-0(Hazardous Substances Data)

Usage

General Description

N-(3-nitrophenyl)propionamide is a chemical compound with the molecular formula C9H10N2O4. It is a derivative of propionamide with an attached 3-nitrophenyl group. N-(3-nitrophenyl)propionamide is primarily used as a reagent in organic synthesis and pharmaceutical research. It may also have potential applications in the development of new drugs and pharmaceutical compounds. The 3-nitrophenyl group on N-(3-nitrophenyl)propionamide is an important functional group in organic chemistry, allowing for various chemical reactions and modifications to be carried out. Overall, N-(3-nitrophenyl)propionamide is valuable in chemical research and development for its unique properties and potential applications.

InChI:InChI=1/C9H10N2O3/c1-2-9(12)10-7-4-3-5-8(6-7)11(13)14/h3-6H,2H2,1H3,(H,10,12)

Upstream product

• 802294-64-0 propionic acid 
• 99-09-2 3-nitro-aniline 
• 7664-93-9 sulfuric acid 
• 620-71-3 N-(phenyl)-2-methylacetamide 
• 7697-37-2 nitric acid 
• 108-24-7 acetic anhydride 
• 79-03-8 propionyl chloride 

Downstream Products

• 22987-10-6 1-amino-3-propionylamino-benzene 
• 22185-75-7 N,N-diethyl-N'-propionyl-1,3-benzenediamine 
• 85929-33-5 (E)-N-(2-((2-bromo-6-cyano-4-nitrophenyl)diazenyl)-5-(diethylamino)phenyl)propionamide 
• 94510-18-6 N-[2-(2,6-Dicyano-4-nitro-phenylazo)-5-diethylamino-phenyl]-propionamide 
• 56935-81-0 N-[2-(2-Bromo-4,6-dinitro-phenylazo)-5-diethylamino-phenyl]-propionamide 
• 56968-03-7 N-[2-(2-Cyano-4,6-dinitro-phenylazo)-5-diethylamino-phenyl]-propionamide 
• 129882-17-3 N-(3-butylaminophenyl)propionamide 
• 129882-11-7 N-[3-(Butyl-phenethyl-amino)-phenyl]-propionamide 

Relevant articles and documents

Discovery of novel quinazoline derivatives as potent PI3Kδ inhibitors with high selectivity

Inhibition of PI3Kδ has been proved to be an efficacious strategy for the treatment of hematological malignancies where the PI3K/Akt signaling pathway is hyperactive. Herein, a series of quinazoline derivatives bearing acrylamide fragment were prepared using skeleton-deconstruction strategy. The preliminary bioactivity evaluation resulted in the discovery of lead compound 15c. Compound 15c exhibited excellent enzyme activity against PI3Kδ (IC50 = 27.5 nM) compared with BEZ235 as well as the significant anti-proliferation activities. With the high selectivity over other PI3K isoforms and potent effects on PI3K/Akt pathway, 15c can be identified as a promising PI3Kδ inhibitor worthy of further profiling.

An efficient protocol for the amidation of carboxylic acids promoted by trimethyl phosphite and iodine

A practical, one-pot protocol is described for the conversion of carboxylic acids into amides through carboxyl activation by the reagent combination of trimethyl phosphite and iodine. This method integrates several advantages: (1) it allows amines to be chemoselectively acylated with excellent results in the presence of sulfur and oxygen nucleophiles; (2) the method shows wide generality in respect of solvent, base, and substrate; (3) the reagents used are widely available and much less expensive than common coupling reagents, and (4) the process is remarkably convenient, permitting extraction, recrystallization, and column chromatography as optional work-up procedures. The chemoselectivity and generality of the method, the low cost, and wide availability of reagents combined with the ease of use make it a very favorable process.