7470-64-6

Basic information

• Product Name: 3-(morpholin-4-yl)-1-(phenanthren-3-yl)propan-1-one
• CAS NO: 7470-64-6
• Molecular Formula: C₂₁H₂₁NO₂
• Molecular Weight: 319.3969
• Mol File: 7470-64-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 533.7°C at 760 mmHg
• Flash Point: 276.6°C
• Density: 1.181g/cm³
• Vapor Pressure: 1.81E-11mmHg at 25°C
• Refractive Index: 1.647
• CAS DataBase Reference: 3-(morpholin-4-yl)-1-(phenanthren-3-yl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(morpholin-4-yl)-1-(phenanthren-3-yl)propan-1-one(7470-64-6)
• EPA Substance Registry System: 3-(morpholin-4-yl)-1-(phenanthren-3-yl)propan-1-one(7470-64-6)

Safety Data

• Hazardous Substances Data: 7470-64-6(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 2039-76-1 1-(phenanthren-3-yl)ethanone 
• 10024-89-2 morpholin hydrochloride 

Relevant articles and documents

Evaluation of alkylating and intercalating properties of mannich bases for cytotoxic activity

A series of new "hybrid compounds", Mannich base derivatives of planar polycyclic/heterocyclic starting materials, was designed and synthesized. The structures of the compounds were confirmed by spectroscopic methods and elemental analysis. Cytotoxicity of compounds was investigated in three cancer cell lines (PC3, HeLa, and MCF7) and one non-tumoral cell line (293 HEK). We tested the DNA-intercalating capability of the molecules by ethidium bromide (EtBr) fluorescence displacement experiment. Compounds' alkylation potency was investigated via in vitro incubation test using 2-mercaptoethanol, a biomimetic nucleophile. The five of the compounds (7s, 9d, 10b, 11b, 12c) are reported for first time in the literature. Our results suggest that compound 9d has a biological activity close to the reference compound doxorubicin, an intercalating agent in clinical use.