74714-05-9

Basic information

• Product Name: Thiophene, 3,4-bis(phenylmethyl)-
• CAS NO: 74714-05-9
• Molecular Formula: C18H16S
• Molecular Weight: 264.391
• Mol File: 74714-05-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Thiophene, 3,4-bis(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiophene, 3,4-bis(phenylmethyl)-(74714-05-9)
• EPA Substance Registry System: Thiophene, 3,4-bis(phenylmethyl)-(74714-05-9)

Safety Data

• Hazardous Substances Data: 74714-05-9(Hazardous Substances Data)

Upstream product

• 3141-26-2 3,4-dibromothiophene 
• 6921-34-2 benzylmagnesium chloride 
• 62673-31-8 benzyl(bromo)zinc 

Downstream Products

• 1079371-44-0 3,4-dibenzylthiophene-S-oxide 
• 1079371-43-9 3,4-dibenzylthiophenium bis(methoxycarbonyl)methylide 
• 25347-40-4 2,3-dimethyl-1,4-diphenylbutane 

Relevant articles and documents

NICKEL-PHOSPHINE COMPLEX-CATALYZED GRIGNARD COUPLING-II; GRIGNARD COUPLING OF HETEROCYCLIC COMPOUNDS

A general, versatile method for alkylation and arylation of haloheterocyclic compounds is reported.In the presence of a catalytic quantity of , where dppp stands for Ph2P(CH2)3PPh2, bromothiophenes, halopyridines, haloquinoline, and haloisoquinolines reacted with alkyl and aryl Grignard reagents at room temperature or at ether refluxing temperature to give the cross-coupling products.The coupling reactions has been applied to the synthesis of isoquinoline alkaloids.Reactivities of 2-thienyl and 2-pyridyl Grignard reagents have also been examined.

SELECTIVE MONO-ALKYLATION AND ARYLATION OF AROMATIC DIHALIDES BY PALLADIUM-CATALYZED CROSS-COUPLING WITH THE GRIGNARD AND ORGANOZINC REAGENTS

Dibromobenzene, dibromothiophenes, dichloro- and dibromopyridine are highly selectively mono-alkylated and arylated with Grignard or organozinc reagents in the presence of palladium complexes as catalysts.