7472-97-1

Basic information

• Product Name: 2,3-diphenylpropanaMide
• Synonyms: 2,3-diphenylpropanaMide
• CAS NO: 7472-97-1
• Molecular Formula: C₁₅H₁₅NO
• Molecular Weight: 225.2857
• Mol File: 7472-97-1.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 397.7 °C at 760 mmHg
• Flash Point: 194.3 °C
• Appearance: /
• Density: 1.12 g/cm³
• Vapor Pressure: 1.56E-06mmHg at 25°C
• Refractive Index: 1.597
• CAS DataBase Reference: 2,3-diphenylpropanaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-diphenylpropanaMide(7472-97-1)
• EPA Substance Registry System: 2,3-diphenylpropanaMide(7472-97-1)

Safety Data

• Hazardous Substances Data: 7472-97-1(Hazardous Substances Data)

Usage

General Description

2,3-Diphenylpropanamide, also known as DPPA, is an organic compound with the chemical formula C15H15NO. It is a white solid that is commonly used in organic synthesis as a reagent for the preparation of amides, esters, and other functional groups. DPPA is a versatile building block in the production of pharmaceuticals, agrochemicals, and other fine chemicals. It is known for its ability to efficiently convert carboxylic acids to amides and is widely used in the pharmaceutical industry for the synthesis of various drugs. Additionally, DPPA is also used in the production of perfumes and fragrances as well as in the manufacturing of plastics and polymers.

InChI:InChI=1/C15H15NO/c16-15(17)14(13-9-5-2-6-10-13)11-12-7-3-1-4-8-12/h1-10,14H,11H2,(H2,16,17)

Upstream product

• 3333-14-0 2,3-diphenylpropionitrile 
• 56042-76-3 2,3-diphenylpropionyl chloride 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 140-29-4 phenylacetonitrile 
• 6114-57-4 (Z)-2,3-diphenylacrylonitrile 
• 100-51-6 benzyl alcohol 
• 73747-26-9 2-benzyl-3-oxo-2-phenylbutanenitrile 
• 100-52-7 benzaldehyde 
• 2510-95-4 2,3-diphenylacrylonitrile 

Downstream Products

• 3333-14-0 2,3-diphenylpropanenitrile 
• 3536-29-6 2,3-diphenyl-1-propanol 
• 103-30-0 (E)-1,2-diphenyl-ethene 
• 5415-80-5 2,3-diphenylpropan-1-amine 
• 94942-89-9 2,3-diphenylpropanoic acid 

Relevant articles and documents

Tandem Acceptorless Dehydrogenative Coupling-Decyanation under Nickel Catalysis

The development of new catalytic processes based on abundantly available starting materials by cheap metals is always a fascinating task and marks an important transition in the chemical industry. Herein, a nickel-catalyzed acceptorless dehydrogenative coupling of alcohols with nitriles followed by decyanation of nitriles to access diversely substituted olefins is reported. This unprecedented C=C bond-forming methodology takes place in a tandem manner with the formation of formamide as a sole byproduct. The significant advantages of this strategy are the low-cost nickel catalyst, good functional group compatibility (ether, thioether, halo, cyano, ester, amino, N/O/S heterocycles; 43 examples), synthetic convenience, and high reaction selectivity and efficiency.

Method for synthesizing aromatic acetamide

The preparation method comprises the following steps: dissolving a compound 1 and a compound 2 in an organic solvent, adding a catalyst, a ligand and an alkaline substance, reacting for 2-10 hours at the temperature of 80-160 DEG C in a protective atmosphere, and post-treating the obtained reaction liquid to obtain a compound 3. According to the method, aryl acetamide is synthesized by using alcohol and aryl acetonitrile in one step, so that not only is the use of a toxic alkylating reagent avoided, but also the amide synthesis step is reduced, and the cost is saved; and no by-product is generated in the reaction process, so that the atom utilization rate reaches 100%, and the development requirement of green chemistry is met.

Synthesis of β-hydroxyamides through ruthenium-catalyzed hydration/transfer hydrogenation of β-ketonitriles in water: Scope and limitations

A cascade process for the straightforward one-pot conversion of β-ketonitriles into β-hydroxyamides is presented. The process, that proceeds in water employing the arene-ruthenium(II) complex [RuCl2(η6-p-cymene){P(4-C6H4F)2Cl}] as catalyst in combination with sodium formate, involves the initial hydration of the β-ketonitrile substrates to generate the corresponding β-ketoamide intermediates, which subsequently undergo the transfer hydrogenation (TH) of the carbonyl group. Employing a family of forty different β-ketonitriles, featuring diverse substitution patterns, the scope and limitations of the process have been established.