7472-97-1Relevant articles and documents
Base-controlled chemoselectivity: direct coupling of alcohols and acetonitriles to synthesise α-alkylated arylacetonitriles or acetamides
Bai, Liang,Ge, Min-Tong,Li, Chen,Qiu, Yuan-Rui,Wang, Ying,Xia, Ai-Bao,Xu, Dan-Qian
, p. 15200 - 15204 (2021/09/06)
We achieved chemoselective synthesis of α-alkylated arylacetonitriles and acetamides by combining Ir complex-catalysed direct coupling of alcohols and nitriles by a simple adjustment of the base. Methanol and ethanol performed well as the alkylating reagents. This method of acetonitrile alkylation provided a novel approach for carbon chain extension.
Method for synthesizing aromatic acetamide
-
Paragraph 0026-0040, (2021/08/07)
The preparation method comprises the following steps: dissolving a compound 1 and a compound 2 in an organic solvent, adding a catalyst, a ligand and an alkaline substance, reacting for 2-10 hours at the temperature of 80-160 DEG C in a protective atmosphere, and post-treating the obtained reaction liquid to obtain a compound 3. According to the method, aryl acetamide is synthesized by using alcohol and aryl acetonitrile in one step, so that not only is the use of a toxic alkylating reagent avoided, but also the amide synthesis step is reduced, and the cost is saved; and no by-product is generated in the reaction process, so that the atom utilization rate reaches 100%, and the development requirement of green chemistry is met.
Synthesis of β-hydroxyamides through ruthenium-catalyzed hydration/transfer hydrogenation of β-ketonitriles in water: Scope and limitations
González-Fernández, Rebeca,Crochet, Pascale,Cadierno, Victorio
, p. 90 - 101 (2019/06/18)
A cascade process for the straightforward one-pot conversion of β-ketonitriles into β-hydroxyamides is presented. The process, that proceeds in water employing the arene-ruthenium(II) complex [RuCl2(η6-p-cymene){P(4-C6H4F)2Cl}] as catalyst in combination with sodium formate, involves the initial hydration of the β-ketonitrile substrates to generate the corresponding β-ketoamide intermediates, which subsequently undergo the transfer hydrogenation (TH) of the carbonyl group. Employing a family of forty different β-ketonitriles, featuring diverse substitution patterns, the scope and limitations of the process have been established.