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74733-28-1

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74733-28-1 Usage

General Description

Methyl 4-(bromomethyl)-2-methylbenzoate is a chemical compound with the molecular formula C10H11BrO2. It is a derivative of benzoic acid and belongs to the ester group. Methyl 4-(bromomethyl)-2-methylbenzoate consists of a benzene ring substituted with a bromomethyl group and a methyl group. It is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of various compounds. Its bromomethyl group makes it reactive and suitable for cross-coupling reactions, making it a valuable intermediate in the production of various pharmaceuticals and chemical products.

Check Digit Verification of cas no

The CAS Registry Mumber 74733-28-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,7,3 and 3 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 74733-28:
(7*7)+(6*4)+(5*7)+(4*3)+(3*3)+(2*2)+(1*8)=141
141 % 10 = 1
So 74733-28-1 is a valid CAS Registry Number.

74733-28-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl 4-(bromomethyl)-2-methylbenzoate

1.2 Other means of identification

Product number -
Other names 4-bromomethyl-2-methyl-benzoic acid methyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:74733-28-1 SDS

74733-28-1Relevant articles and documents

A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase to Counter Nonalcoholic Steatohepatitis

Schmidt, Jurema,Rotter, Marco,Weiser, Tim,Wittmann, Sandra,Weizel, Lilia,Kaiser, Astrid,Heering, Jan,Goebel, Tamara,Angioni, Carlo,Wurglics, Mario,Paulke, Alexander,Geisslinger, Gerd,Kahnt, Astrid,Steinhilber, Dieter,Proschak, Ewgenij,Merk, Daniel

supporting information, p. 7703 - 7724 (2017/10/06)

Nonalcoholic steatohepatitis arising from Western diet and lifestyle is characterized by accumulation of fat in liver causing inflammation and fibrosis. It evolves as serious health burden with alarming incidence, but there is no satisfying pharmacological therapy to date. Considering the disease's multifactorial nature, modulation of multiple targets might provide superior therapeutic efficacy. In particular, farnesoid X receptor (FXR) activation that revealed antisteatotic and antifibrotic effects in clinical trials combined with inhibition of soluble epoxide hydrolase (sEH) as anti-inflammatory strategy promises synergies. To exploit this dual concept, we developed agents exerting partial FXR agonism and sEH inhibitory activity. Merging known pharmacophores and systematic exploration of the structure-activity relationship on both targets produced dual modulators with low nanomolar potency. Extensive in vitro characterization confirmed high dual efficacy in cellular context combined with low toxicity, and pilot in vivo data revealed favorable pharmacokinetics as well as engagement on both targets in vivo.

Mild Benzylic Monobromination of Methyl Toluates in Aqueous CTAB

Reddy, Kancharla Rajendar,Rajanna, Kamatala C.,Venkateswarlu, Marri,Saiprakash

, p. 2485 - 2487 (2015/07/27)

A strategy has been developed for the regioselective monobromination of methyl toluates by using tert-butylhydrogen peroxide and potassium bromide (TBHP/KBr) in a cetyltrimethylammonium bromide (CTAB) micellar medium. Ultrasonic and microwave-assisted protocols recorded increased rates and product yields under mild reaction conditions, coupled with a straightforward isolation procedure.

Pyridyl inhibitors of hedgehog signalling

-

Page/Page column 113, (2010/10/20)

The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.

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