74772-16-0

Basic information

• Product Name: METHYL 3-(1-PYRROLO)THIOPHENE-2-CARBOXYLATE
• Synonyms: METHYL 3-(1H-PYRROL-1-YL)-2-THIOPHENECARBOXYLATE;METHYL 3-(1H-PYRROL-1-YL)THIOPHENE-2-CARBOXYLATE;METHYL 3-(1-PYRROLO)THIOPHENE-2-CARBOXYLATE;RARECHEM AL BF 1295;3-(1-Pyrrolo)thiophene-2-carboxylic acid methyl eser;METHYL 3-(PYRROL-1-YL)THIOPHENE-2-CARBOXYLATE;Methyl 3-(1-pyrrolyl)thiophene-2-carboxylate, 97%
• CAS NO: 74772-16-0
• Molecular Formula: C₁₀H₉NO₂S
• Molecular Weight: 207.25
• EINECS: -0
• Mol File: 74772-16-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 63-64°C
• Boiling Point: 345.7 °C at 760 mmHg
• Flash Point: 162.9 °C
• Appearance: white or cream powder
• Density: 1.25 g/cm³
• Vapor Pressure: 6.06E-05mmHg at 25°C
• Refractive Index: 1.613
• BRN: 4679860
• CAS DataBase Reference: METHYL 3-(1-PYRROLO)THIOPHENE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3-(1-PYRROLO)THIOPHENE-2-CARBOXYLATE(74772-16-0)
• EPA Substance Registry System: METHYL 3-(1-PYRROLO)THIOPHENE-2-CARBOXYLATE(74772-16-0)

Safety Data

• Safety Statements: 22-24/25
• HazardClass: IRRITANT
• Hazardous Substances Data: 74772-16-0(Hazardous Substances Data)

Usage

General Description

Methyl 3-(1-pyrrolo)thiophene-2-carboxylate is a chemical compound with a molecular formula C10H7NO2S. It is a derivative of thiophene, a heterocyclic compound with a five-membered ring containing four carbon atoms and one sulfur atom. The compound is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and pharmaceutical intermediates. It is also used in the production of agrochemicals and organic compounds. Methyl 3-(1-pyrrolo)thiophene-2-carboxylate is a colorless to light yellow liquid with a characteristic odor, and it is important to handle it with care due to its potential hazards.

InChI:InChI=1/C10H9NO2S/c1-13-10(12)9-8(4-7-14-9)11-5-2-3-6-11/h2-7H,1H3

Upstream product

• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 22288-78-4 Methyl 3-aminothiophene-2-carboxylate 

Downstream Products

• 74772-17-1 3-(1H-pyrrol-1-yl)thiophene-2-carboxylic acid 
• 107073-27-8 (3-Pyrrol-1-yl-thiophen-2-yl)-methanol 
• 175911-95-2 4-Benzyl-piperazine-1-carboxylic acid (3-pyrrol-1-yl-thiophen-2-yl)-amide 
• 175911-97-4 4-(3-Trifluoromethyl-phenyl)-piperazine-1-carboxylic acid (3-pyrrol-1-yl-thiophen-2-yl)-amide 
• 107073-28-9 3-(1H-pyrrol-1-yl)-2-thiophenecarbaldehyde 
• 106723-71-1 methyl-5 pyrrolo<1,2-a>thieno<2,3-e>pyrazine 

Relevant articles and documents

Pd/Cu-catalyzed dual C-H bond carbonylation towards the synthesis of fluorazones

Pd/Cu catalyzed oxidative dual C-H bond activation/carbonylation still remains a great challenge due to the generation of by-products via C-C bond formation. Herein we developed a straightforward Pd/Cu-catalyzed oxidative dual C-H bond carbonylation process to access biologically and pharmaceutically important fluorazones from easily available N-aryl pyrroles and CO. A wide range of functional groups were well tolerated in this transformation, and O2 could be utilized as the only terminal oxidant to promote the oxidative carbonylation process.

Tricyclic oxime ethers

The present invention relates to compounds of formula (I): STR1 wherein A, x, y, R1, R2 and R3 are as defined in the description. The compounds are useful for treating diseases requiring a selective serotonin reuptake site

Pyrrolothienopyrazines: Synthese de la pyrrolothienopyrazine et de la pyrrolothienopyrazine

The synthesis of pyrrolothienopyrazine and pyrrolothienopyrazine is described.These syntheses could be achieved by intramolecular cyclization of 2- (and 3-) (1-pyrrolyl)-3- (and -2)-thienylamines obtained by hydrolysis of carbamates or by cleavage of the corresponding ureas.An original way giving better results was also studied via a Curtius rearrangement by reaction between the azide and aldehyde groupings.The synthesis of 2- (and -3)-(-2-formyl-1-pyrrolyl)-2- (and -3)-thenoylazide is described.