74786-53-1

Basic information

• Product Name: 1-Propanone, 1-(2-methoxyphenyl)-2-methyl-
• Synonyms: 2-(2-Methylprop-1-enyl)-5-nitrothiophen;2-(2-methyl-propenyl)-5-nitro-thiophene
• CAS NO: 74786-53-1
• Molecular Formula: C11H14O2
• Molecular Weight: 178.231
• Mol File: 74786-53-1.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 1-(2-methoxyphenyl)-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 1-(2-methoxyphenyl)-2-methyl-(74786-53-1)
• EPA Substance Registry System: 1-Propanone, 1-(2-methoxyphenyl)-2-methyl-(74786-53-1)

Safety Data

• Hazardous Substances Data: 74786-53-1(Hazardous Substances Data)

Upstream product

• 598-26-5 dimethylketene 
• 100-66-3 methoxybenzene 
• 79-30-1 isobutyryl chloride 
• 578-57-4 2-bromoanisole 
• 14478-14-9 1-acetyloxy-2-methylpropene 
• 2040-24-6 isobutyrylpentamethylbenzene 
• 6609-56-9 2-methoxy-benzonitrile 
• 1068-55-9 isopropylmagnesium chloride 
• 67-56-1 methanol 
• 58824-49-0 1-(2-methoxyphenyl)prop-2-en-1-ol 
• 135-02-4 ortho-anisaldehyde 
• 5561-92-2 1-(2-methoxyphenyl)propan-1-one 
• 579-74-8 2-Methoxyacetophenone 
• 74-88-4 methyl iodide 

Downstream Products

• 109847-38-3 5-(2-methoxy-phenyl)-4-methyl-[1,2]dithiol-3-thione 
• 579-75-9 2-Methoxybenzoic acid 
• 16748-90-6 2,2-dimethylbenzofuran-3(2H)-one 
• 74786-56-4 2-methyl-3-oxo-2,3-dihydrobenzofuran-2-yl acetate 
• 827348-36-7 (R)-2-methyl-1-(2-methoxyphenyl)-1-propanol 
• 6642-39-3 1-(2-methoxy-phenyl)-2-methyl-propan-1-ol 
• 1355253-95-0 C₁₅H₂₄O₂Si 
• 1338935-43-5 5-[(Z)-2-(2'-methoxyphenyl)-3-methylbut-1-en-1-yl]-furo[2,3-d]pyrimidine-2,4-diamine 
• 1196851-94-1 5-[(E)-2-(2'-methoxyphenyl)-3-methylbut-1-en-1-yl]-furo[2,3-d]pyrimidine-2,4-diamine 
• 106701-20-6 2-Chloro-N-(2-methoxy-ethyl)-N-[1-(2-methoxy-phenyl)-2-methyl-propenyl]-acetamide 
• 18228-46-1 1-(p-methoxyphenyl)-2-methylpropan-1-ol 

Relevant articles and documents

Palladium-Catalyzed Synthesis of α-Methyl Ketones from Allylic Alcohols and Methanol

One-pot synthesis of α-methyl ketones starting from 1,3-diaryl propenols or 1-aryl propenols and methanol as a C1 source is demonstrated. This one-pot isomerization-methylation is catalyzed by commercially available Pd(OAc)2 with H2O as the only by-product. Mechanistic studies and deuterium labelling experiments indicate the involvement of isomerization of allyl alcohol followed by methylation through a hydrogen-borrowing pathway in these isomerization-methylation reactions.

Rhodium-Catalyzed Direct Ortho C-H Arylation Using Ketone as Directing Group with Boron Reagent

A general method for selective ortho C-H arylation of ketone, with boron reagent enabled by rhodium complexes with excellent yields, is developed. The transformation is characterized by the use of air-stable Rh catalyst, high monoarylation selectivity, and excellent yields of most of the substrates.

Utilization of MeOH as a C1 Building Block in Tandem Three-Component Coupling Reaction

Ru(II) catalyzed tandem synthesis of α-branched methylated ketones via multicomponent reactions following the hydrogen borrowing process is described. This nonphosphine-based air and moisture stable catalyst efficiently produced various methylated ketones using methanol as a methylating agent. This system was found to be highly effective in three-component coupling between methanol, primary alcohols, and methyl ketones. A proposed catalytic cycle for the α-methylation is supported by DFT calculations as well as kinetic experiments.