7479-20-1

Basic information

• Product Name: 3-(1-METHYL-1H-INDOL-3-YL)-PROPIONIC ACID
• Synonyms: 3-(1-METHYL-1H-INDOL-3-YL)-PROPIONIC ACID;3-(1-methyl-3-indolyl)propanoic acid;3-(1-methylindol-3-yl)propanoic acid;3-(1-methylindol-3-yl)propionic acid
• CAS NO: 7479-20-1
• Molecular Formula: C₁₂H₁₃NO₂
• Molecular Weight: 203.24
• Mol File: 7479-20-1.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 399.6°Cat760mmHg
• Flash Point: 195.4°C
• Appearance: /
• Density: 1.17g/cm³
• Vapor Pressure: 4.21E-07mmHg at 25°C
• Refractive Index: 1.587
• CAS DataBase Reference: 3-(1-METHYL-1H-INDOL-3-YL)-PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1-METHYL-1H-INDOL-3-YL)-PROPIONIC ACID(7479-20-1)
• EPA Substance Registry System: 3-(1-METHYL-1H-INDOL-3-YL)-PROPIONIC ACID(7479-20-1)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 7479-20-1(Hazardous Substances Data)

Usage

General Description

3-(1-methyl-1H-indol-3-yl)-propionic acid, also known as 1-methyltryptophan, is a chemical compound that belongs to the class of indole derivatives. It is a derivative of tryptophan and is commonly used in the synthesis of various pharmaceuticals and biologically active compounds. This chemical is of interest due to its potential application as an anti-inflammatory and immunosuppressive agent, as well as its role in the development of new drugs targeting various diseases. Additionally, it is also used in research and studies related to neurodegenerative disorders, cancer, and autoimmune diseases as a potential therapeutic agent.

InChI:InChI=1/C12H13NO2/c1-13-8-9(6-7-12(14)15)10-4-2-3-5-11(10)13/h2-5,8H,6-7H2,1H3,(H,14,15)

Upstream product

• 855658-22-9 (1-methyl-indol-3-ylmethyl)-malonic acid 
• 57901-08-3 1-methylindole-3-propionic acid methyl ester 
• 830-96-6 Indole-3-propionic acid 
• 74-88-4 methyl iodide 
• 603-76-9 1-methylindole 
• 79-10-7 acrylic acid 
• 19260-05-0 1-methylgramine methiodide 

Downstream Products

• 909568-50-9 N-(2-iodophenyl)-3-(1-methyl-1H-indol-3-yl)propionamide 
• 909568-51-0 N-(4-chloro-2-iodophenyl)-3-(1-methyl-1H-indol-3-yl)propionamide 
• 892386-15-1 N-(2-bromobenzyl)-3-(1-methyl-1H-indol-3-yl)propionamide 
• 909568-59-8 N-(2-iodophenyl)-N-methyl-3-(1-methyl-1H-indol-3-yl)propionamide 
• 909568-60-1 N-(4-chloro-2-iodophenyl)-N-methyl-3-(1-methyl-1H-indol-3-yl)propionamide 
• 909568-62-3 N-(2-bromobenzyl)-N-methyl-3-(1-methyl-1H-indol-3-yl)propionamide 
• 839685-22-2 4-methyl-3-phenyl-1,2,3,4-tetrahydrocyclopenta[b]indol-3-ol 
• 828937-88-8 3-(4-methyl-3-phenyl-1,4-dihydrocyclopenta[b]indol-2-yl)propanenitrile 
• 21355-36-2 N-Methyl-1,2-Phthaloylcarbazol 
• 1242139-62-3 1-(benzyloxy)-6-methylnaphtho[2,3-a]carbazole-5,13-dione 
• 1323359-82-5 7-[4-(dimethylamino)phenyl]-4-methyl-1,4-dihydro-2H-cyclopenta[b]indol-3-one 
• 1323359-54-1 4-methyl-7-(4-nitrophenyl)-1,4-dihydro-2H-cyclopenta[b]indol-3-one 

Relevant articles and documents

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Sodium Iodide/Hydrogen Peroxide-Mediated Oxidation/Lactonization for the Construction of Spirocyclic Oxindole-Lactones

The sodium iodide/hydrogen peroxide-mediated oxidation/lactonization of indolepropionic acids was achieved, affording the corresponding spirocyclic oxindole-lactones in moderate to high yields. This metal-free procedure features mild reaction conditions, non-toxicity and easy handling, with hydrogen peroxide (H2O2) as a clean oxidant. (Figure presented.).

Thee-component, one-pot synthesis of hexahydroazepino[3,4-b]indole and tetrahydro-1H-pyrido[3,4-b]indole derivatives and evaluation of their cytotoxicity

A three-component, four-center Ugi reaction has been developed to produce a novel class of 2-aryl-3-oxo-hexahydroazepino[3,4-b]indole and 2-aryl-3-oxo-tetrahydro-1H-pyrido[3,4-b]indole derivatives in good to high yields. A few of them exhibit moderate cyt