74796-42-2Relevant articles and documents
Geiparvarin analogues. 2. Synthesis and cytostatic activity of 5-(4- arylbutadienyl)-3(2H)-furanones and of N-substituted 3-(4-oxo-2-furanyl)-2- buten-2-yl carbamates
Simoni,Manfredini,Tabrizi,Bazzanini,Baraldi,Balzarini,De Clercq
, p. 3172 - 3176 (2007/10/02)
In an attempt to determine some of the structural features of geiparvarin (1) that account for its cytostatic activity in vitro, a series of geiparvarin analogues (10a-i, l, 12, and 14-16) which contain novel modifications in the region of the olefinic do
Synthesis and Configurational Assignment of Geiparvarin: A Novel Antitumor Agent
Jerris, Paula J.,Smith, Amos B.
, p. 577 - 585 (2007/10/02)
This report presents the first total synthesis of geiparvarin as well as assignment of configuration of the previously undefined trisubstituted olefin.A central aspect of this synthetic adventure leading to this novel antitumor agent which possesses the 3