74800-45-6Relevant articles and documents
Co-delivery of Cu(I) chelator and chemotherapeutics as a new strategy for tumor theranostic
Chen, Hongyi,Chen, Qinjun,Chu, Yongchao,Guo, Qin,Guo, Zhongyuan,Jiang, Chen,Jiang, Liping,Li, Chao,Liu, Peixin,Sun, Tao,Yu, Haijun,Zhang, Guangping,Zhang, Yiwen,Zhang, Yujie,Zhou, Wenxi
, p. 483 - 496 (2020/03/03)
Chelating Cu from tumors has been verified as an effective and promising strategy for cancer therapy through antiangiogenesis. However, systematic removal Cu by injecting with Cu chelators will result unavoidable side effects, since Cu is indispensable to the body. In this work, a micelle targeting to tumors' newborn vessels based on a polypeptide was developed to co-load DOX and Probe X, which can go through an “OFF-to-ON” procedure to report the Cu+-capture events in vivo in a real-time way by giving near infrared (NIR) fluorescence and photoacoustic signal. By co-delivering antiangiogenesis and chemotherapeutic reagents, the tumor can be significantly suppressed, meanwhile with a low systematic toxicity. Hopefully, this work can offer new insights in designing sophisticated antitumor strategy.
A near-infrared cyanine dye preparation method (by machine translation)
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, (2019/01/14)
The invention discloses a having excellent light stability of the near-infrared cyanine dye preparation method and use, the dye of the formula I as shown in the structural formula, R1 Hydrogen, methyl, in any one of a carboxyl group; R2 Hydrogen, methyl, alkoxy in any one of; X- Is iodine ion, bromide ion in any one of; n=1 - 5 is any integer. The dye through chemical bonding will be blocked piperidine structure unit introduced into the cycloheptane boeki indole cyanine in the mother's body, such that the resulting dye has good light stability, in the near-infrared region with absorption and emission, and has good photosensitive, photo-thermal characteristic, so that the fabric is colored, near-infrared fluorescence imaging, the photodynamic treatment, heat treating the field have good application prospect. (by machine translation)
Photophysical properties of near-IR cyanine dyes and their application as photosensitizers in dye sensitized solar cells
Ghann, William,Kang, Hyeonggon,Emerson, Edward,Oh, Jiyoung,Chavez-Gil, Tulio,Nesbitt, Fred,Williams, Richard,Uddin, Jamal
, p. 123 - 131 (2017/08/26)
The photophysical properties of eight structurally diverse near-infrared cyanine dyes were investigated with respect to their structural features and potential use as light-harvesting sensitizers of dye sensitized solar cells. The absorption, emission, and lifetime characteristics of the dyes were assessed under a variety of conditions. The photophysical properties and sensitizing efficiency of three of the eight dyes, with an additional six-membered cyclic ring, were markedly different from the other five. The dyes absorbed light of wavelength within the range of 779–823 nm and emitted within the range of 832–876 nm.The dyes had fluorescence quantum yield in the range of 14–22%. The surface morphology and elemental analysis of the cyanine dye sensitized photoanodes were characterized via Field-Emission Scanning Microscopy Imaging (FESEM) and Transmission Electron Microscopy (TEM). The performance of the fabricated cyanine dye sensitized solar cells was assessed via current-voltage and electrochemical impedance spectroscopic measurements. The solar-to-electric power conversion efficiency ranged from 0.04% to 0.24%.
