74839-10-4Relevant articles and documents
Synthetic and Biosynthetic Studies of Porphyrins. Part 9. Synthesis of Isocoproporphyrin, Dehydroisocoproporphyrin, and De-ethylisocopropophyrin
Jackson, Anthony H.,Lash, Timothy D.,Ryder, David J.
, p. 287 - 298 (2007/10/02)
The title compounds, which were extracted by patients suffering from porphyria cutanea tarda or rats poisoned with hexachlorobenzene have been synthesized by the b-oxobilane route.Isocoproporphyrin tetramethyl ester (7a) were prepared from pyrromethanes c
Biosynthesis of Porphyrins and Related Macrocycles. Part 13. Structure of the Protoporphyrin Isomer derived from Coproporphyrinogen lV by the Action of Beef-Liver Coproporphyrinogenase: Synthesis of Protoporphyrin Xlll
Battersby, Alan R.,Hamilton, Andrew D.,McDonald, Edward,Mombelli, Luisa,Wong, Oi-Hoong
, p. 1283 - 1289 (2007/10/02)
Coproporphyrinogen lV (8) is synthesised and is oxidatively decarboxylated by coproporphyrinogenase from beef-liver to produce, after aromatisation, a porphyrin proved to be protoporphyrin Xlll (11) by spectroscopy and by unambiquous synthesis; the synthesis route is described.A monovinylporphyrin, derived from an intermediate for the conversion (8) -> (11), is also isolated.The importance of these results for earlier biosynthetic studies with pyrromethanes is discussed.