74897-46-4Relevant articles and documents
Direct N-Alkylation and Kemp Elimination Reactions of 1-Sulfonyl-1H-Indazoles
Tang, Meng,Chu, Bingjie,Chang, Xiaowei
, p. 2109 - 2116 (2018/07/31)
The reactions of 1-sulfonyl-1H-indazoles under basic conditions are discussed, and the direct N-alkylation and Kemp elimination reactions of these compounds are reported. A series of 2-(p-tosylamino)benzonitriles and N-alkyl indazoles were prepared in good yields. Moreover, the 2-(p-tosylamino)benzonitriles could be transformed into a diverse range of important derivatives in a one-pot reaction. This method was successfully applied to the total syntheses of quindolinone and cryptolepinone; quindolinone was prepared in a one-pot reaction from 1-sulfonyl-1H-indazole.
Substituted 5H-pyrimido[5,4-b]indoles
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, (2008/06/13)
Substituted 5H-pyrimido[5,4-b]indoles of Formula I STR1 wherein R 2 is halogen; the oxadiazolyl group STR2 wherein R"" is lower alkyl with up to 3 carbon atoms; C 1-5 -alkyl, cycloalkyl, aralkyl, or aryl; OR I, SO n R I with n being 0, 1, or 2, or STR3 wherein R I is hydrogen, C 1-5 -alkyl, cycloalkyl, aralkyl, or aryl; STR4 wherein R II and R III are hydrogen, C 1-5 -alkyl, C 3-5 -alkenyl, cycloalkyl, aralkyl, aryl, or, with the connecting N-atom, a 5- or 6-membered heterocyclic ring; andR A is hydrogen; the oxadiazolyl group STR5 wherein R"" is lower alkyl with up to 3 carbon atoms; halogen, nitro, OR I, SO n R I with n being 0, 1, or 2, STR6 wherein R I is hydrogen, C 1-5 -alkyl, cycloalkyl, aralkyl, or aryl; STR7 wherein R II and R III are hydrogen, C 1-5 -alkyl, cycloalkyl, C 3-5 -alkenyl, aralkyl, aryl, or, with the connecting N-atom, a 5- or 6-membered heterocyclic ring; orPO(OR) 2wherein R is C 1-5 -alkyl, exhibit strong affinity for binding to benzodiazepine receptors.The novel compounds are suitable for use in psychopharmaceutical preparations.
