74915-59-6

Basic information

• Product Name: 11β,17β-dihydroxy-21-trifluoromethyl-17α-pregna-1,4-dien-20-yn-3-one
• Synonyms: 11β,17β-dihydroxy-21-trifluoromethyl-17α-pregna-1,4-dien-20-yn-3-one
• CAS NO: 74915-59-6
• Molecular Weight: 394.434
• Mol File: 74915-59-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 11β,17β-dihydroxy-21-trifluoromethyl-17α-pregna-1,4-dien-20-yn-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 11β,17β-dihydroxy-21-trifluoromethyl-17α-pregna-1,4-dien-20-yn-3-one(74915-59-6)
• EPA Substance Registry System: 11β,17β-dihydroxy-21-trifluoromethyl-17α-pregna-1,4-dien-20-yn-3-one(74915-59-6)

Safety Data

• Hazardous Substances Data: 74915-59-6(Hazardous Substances Data)

Upstream product

• 661-54-1 3,3,3-trifluoroprop-1-yne 
• 898-84-0 (8S,9S,10R,11S,13S,14S)-11-Hydroxy-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-6H-cyclopenta[a]phenanthrene-3,17-dione 

Relevant articles and documents

17α-Alkynyl-11β,17-dihydroxyandrostane derivatives: A new class of potent glucocorticoids

Replacement of the characteristic dihydroxyacetone side chain of corticoids by a 17α-alkynyl-17β-hydroxy moiety was investigated.It was found that, in particular, the 17α-propynyl substitution is favorable for high local anti-inflammatory activity with reduced systemic effects.Moreover, these compounds were found to be devoid of any affinity for the aldosterone receptor, and may thus be considered as pure glucocorticoids.