749196-48-3Relevant articles and documents
Synthesis of 2-Amino-4-pyrimidinones from Resin-Bound Guanidines Prepared Using Bis(allyloxycarbonyl)-Protected Triflylguanidine
Zapf, Christoph W.,Goodman, Murray
, p. 10092 - 10097 (2007/10/03)
We have synthesized novel heterocyclic compounds from resin-bound guanidines. For this purpose, an amine immobilized on a solid support was acylated with protected amino acids. Following the deprotection, the liberated amines were guanidinylated utilizing a new member of the family of diurethane-protected triflyl guanidine reagents, N,N′ -bis(allyloxycarbonyl)-N′-triflylguanidine. The deprotected guanidines were subsequently regioselectively cyclized with β-keto esters yielding novel compounds containing heterocyclic structures in high purities.
