74936-81-5 Usage
Description
2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid is an organic compound with a complex chemical structure, characterized by its dihydropyridine ring and nitrophenyl group. It is a key intermediate in the synthesis of certain pharmaceutical compounds, particularly calcium channel blockers.
Uses
Used in Pharmaceutical Industry:
2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid is used as a key intermediate in the synthesis of benidipine hydrochloride metabolites. Benidipine is a potent and long-acting calcium antagonist that is currently being studied for its potential use as an antihypertensive agent and as a treatment for angina.
In the preparation of benidipine hydrochloride metabolites, this compound plays a crucial role in the development of a medication that could help manage high blood pressure and alleviate symptoms of angina, making it an important component in the pharmaceutical industry's efforts to combat cardiovascular diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 74936-81-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,9,3 and 6 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 74936-81:
(7*7)+(6*4)+(5*9)+(4*3)+(3*6)+(2*8)+(1*1)=165
165 % 10 = 5
So 74936-81-5 is a valid CAS Registry Number.
74936-81-5Relevant articles and documents
Synthesis of expected metabolites of benidipine hydrochloride
Muto,Kuroda,Kawato,Nishikawa,Nakamizo
, p. 1666 - 1670 (2007/10/02)
(±)-(R*)-2,6-Dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5- dicarboxylic acid (R*)-1-benzyl-3-piperidinyl ester, methyl ester hydrochloride (benidipine hydrochloride, KW-3049, 1) a highly potent and long-acting calcium antagonistic 1,4-dihydropyridine derivative, is now under clinical study as an antihypertensive and as an antianginal agent. In order to confirm the structures of the metabolites of KW-3049, 19 compounds were prepared. Among then 11 compounds were found to be metabolites (the compounds 2, 3, 6, 8, 14, 15, 16, 28, 31, 32 and 34) of KW-3049 in rats and/or dogs.