7496-72-2

Basic information

• Product Name: 2-(4-bromophenyl)indolizine
• Synonyms: 2-(4-Bromophenyl)indolizine; 2-(4-Bromo-phenyl)-indolizine; Indolizine, 2-(4-bromophenyl)-
• CAS NO: 7496-72-2
• Molecular Formula: C₁₄H₁₀BrN
• Molecular Weight: 272.1399
• Mol File: 7496-72-2.mol
• Article Data: 11

Chemical Properties

• Density: 1.38g/cm³
• Refractive Index: 1.644
• CAS DataBase Reference: 2-(4-bromophenyl)indolizine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-bromophenyl)indolizine(7496-72-2)
• EPA Substance Registry System: 2-(4-bromophenyl)indolizine(7496-72-2)

Safety Data

• Hazardous Substances Data: 7496-72-2(Hazardous Substances Data)

Usage

Compound class

Indolizine

Structural characteristic

Bromine atom attached to a phenyl group in the 2-position of the indolizine ring

Potential applications

Organic synthesis, medicinal chemistry, and materials science

Uses

Building block for the synthesis of various organic compounds and pharmaceuticals

Reactivity

Imparted by bromine substituent

Properties

Unique structure and properties that can be utilized in chemical reactions and material design

Versatility

Valuable chemical compound with a range of potential uses and applications

Upstream product

• 82746-41-6 1-(2-(4-bromophenyl)-2-oxoethyl)-2-methylpyridinium bromide 
• 109-06-8 α-picoline 
• 99-73-0 para-bromophenacyl bromide 
• 99-90-1 para-bromoacetophenone 

Downstream Products

• 77832-45-2 [2-(4-Bromo-phenyl)-indolizin-3-yl]-(3,5-dibromo-4-hydroxy-phenyl)-methanone 
• 88273-94-3 Toluene-4-sulfonic acid 4-[2-(4-bromo-phenyl)-indolizine-3-carbonyl]-2-chloro-phenyl ester 
• 88273-82-9 Toluene-4-sulfonic acid 2-bromo-4-[2-(4-bromo-phenyl)-indolizine-3-carbonyl]-phenyl ester 
• 77832-51-0 [2-(4-Bromo-phenyl)-indolizin-3-yl]-(3,5-dichloro-4-hydroxy-phenyl)-methanone 
• 77823-44-0 [2-(4-Bromo-phenyl)-indolizin-3-yl]-(3-chloro-4-hydroxy-phenyl)-methanone 
• 77823-31-5 (3-Bromo-4-hydroxy-phenyl)-[2-(4-bromo-phenyl)-indolizin-3-yl]-methanone 
• 79286-14-9 [2-(4-Bromo-phenyl)-indolizin-3-yl]-[3-chloro-4-(3-dipropylamino-propoxy)-phenyl]-methanone; compound with oxalic acid 
• 79285-91-9 [3-Bromo-4-(3-dibutylamino-propoxy)-phenyl]-[2-(4-bromo-phenyl)-indolizin-3-yl]-methanone; compound with oxalic acid 
• 79286-15-0 [2-(4-Bromo-phenyl)-indolizin-3-yl]-[3-chloro-4-(3-dibutylamino-propoxy)-phenyl]-methanone; compound with oxalic acid 
• 79283-29-7 [2-(4-Bromo-phenyl)-indolizin-3-yl]-[3,5-dichloro-4-(3-dipropylamino-propoxy)-phenyl]-methanone; compound with oxalic acid 
• 79283-31-1 [2-(4-Bromo-phenyl)-indolizin-3-yl]-[3,5-dichloro-4-(3-dibutylamino-propoxy)-phenyl]-methanone; compound with oxalic acid 
• 1029804-24-7 2-(4-morpholin-4-ylphenyl)indolizine 
• 1043871-87-9 3-{1-[2-(4-bromophenyl)-indolizin-3-yl]-but-3-enyl}-1H-indole 
• 1187471-79-9 4-[2-(4-bromophenyl)indolizin-3-yl]-2-chloroquinazoline 

Relevant articles and documents

Oxidation Potential-Guided Electrochemical Radical-Radical Cross-Coupling Approaches to 3-Sulfonylated Imidazopyridines and Indolizines

Oxidation potential-guided electrochemical radical-radical cross-coupling reactions between N-heteroarenes and sodium sulfinates have been established. Thus, simple cyclic voltammetry measurement of substrates predicts the likelihood of successful radical-radical coupling reactions, allowing the simple and direct synthetic access to 3-sulfonylated imidazopyridines and indolizines. The developed electrochemical radical-radical cross-coupling reactions to sulfonylated N-heteroarenes boast the green synthetic nature of the reactions that are oxidant- and metal-free.

Mechanochemical Synthesis of 1,2-Diketoindolizine Derivatives from Indolizines and Epoxides Using Piezoelectric Materials

A simple and efficient mechanochemical-induced approach for the synthesis of 1,2-diketoindolizine derivatives has been developed. BaTiO3 was used as the piezoelectric material in this transformation. This method features no usage of solvent, simple experimental operation, scalable potential, and high conversion efficiency, which make it attractive and practical.

NH4I-catalyzed C–S bond formation via an oxidation relay strategy: Efficient access to dithioether decorated indolizines

An efficient NH4I-catalyzed C–H/S–H cross-coupling reaction of indolizines with thiols is reported. Compared to previous methods, this environmentally friendly oxidation relay strategy uses O2 as an oxidant to afford dithioether decorated indolizines in up to 98% yield. Promising results have been obtained, indicating the high applicability and atom economy of this method.