7496-81-3

Basic information

• Product Name: 2-(4-methylphenyl)indolizine
• Synonyms: 2-(4-methylphenyl)indolizine;2-(P-TOLYL)INDOLIZINE
• CAS NO: 7496-81-3
• Molecular Formula: C₁₅H₁₃N
• Molecular Weight: 207.27
• Mol File: 7496-81-3.mol
• Article Data: 12

Chemical Properties

• Melting Point: 222 °C
• Appearance: /
• Density: 1.04g/cm³
• Refractive Index: 1.599
• CAS DataBase Reference: 2-(4-methylphenyl)indolizine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methylphenyl)indolizine(7496-81-3)
• EPA Substance Registry System: 2-(4-methylphenyl)indolizine(7496-81-3)

Safety Data

• Hazardous Substances Data: 7496-81-3(Hazardous Substances Data)

Usage

General Description

2-(4-methylphenyl)indolizine is a chemical compound containing a five-membered ring fused to a six-membered ring with a methylphenyl group attached to it. It is a heterocyclic compound with potential pharmacological properties. It has been studied for its potential as an anti-cancer agent and has shown promising results in inhibiting the growth of cancer cells in vitro. Its unique structure and potential biological activity make it an interesting compound for further research and development in the field of medicinal chemistry.

InChI:InChI=1/C15H13N/c1-12-5-7-13(8-6-12)14-10-15-4-2-3-9-16(15)11-14/h2-11H,1H3

Upstream product

• 82746-47-2 p-methylphenacyl-α-picolinium bromide 
• 109-06-8 α-picoline 
• 619-41-0 4-(bromoacetyl)toluene 
• 122-00-9 para-methylacetophenone 

Downstream Products

• 85257-93-8 Sodium; 2,6-dibromo-4-(2-p-tolyl-indolizine-3-carbonyl)-phenolate 
• 88265-29-6 Toluene-4-sulfonic acid 2-bromo-4-(2-p-tolyl-indolizine-3-carbonyl)-phenyl ester 
• 82746-39-2 1,3-dinitro-2-(p-methylphenyl)indolizine 
• 77823-41-7 (3-Chloro-4-hydroxy-phenyl)-(2-p-tolyl-indolizin-3-yl)-methanone 
• 77823-28-0 (3-Bromo-4-hydroxy-phenyl)-(2-p-tolyl-indolizin-3-yl)-methanone 
• 79286-12-7 [3-Chloro-4-(3-dipropylamino-propoxy)-phenyl]-(2-p-tolyl-indolizin-3-yl)-methanone; compound with oxalic acid 
• 1210434-91-5 2-(4-methylphenyl)-3-(4,6-dinitro-2,1,3-benzoxadiazol-7-yl)indolizine 
• 1210434-94-8 2-(4-methylphenyl)-3-(4,6-dinitro-1-oxido-2,1,3-benzoxadiazol-7-yl)indolizine 
• 1210435-01-0 C₂₁H₁₃N₅O₆ 

Relevant articles and documents

Oxidation Potential-Guided Electrochemical Radical-Radical Cross-Coupling Approaches to 3-Sulfonylated Imidazopyridines and Indolizines

Oxidation potential-guided electrochemical radical-radical cross-coupling reactions between N-heteroarenes and sodium sulfinates have been established. Thus, simple cyclic voltammetry measurement of substrates predicts the likelihood of successful radical-radical coupling reactions, allowing the simple and direct synthetic access to 3-sulfonylated imidazopyridines and indolizines. The developed electrochemical radical-radical cross-coupling reactions to sulfonylated N-heteroarenes boast the green synthetic nature of the reactions that are oxidant- and metal-free.

Mechanochemical Synthesis of 1,2-Diketoindolizine Derivatives from Indolizines and Epoxides Using Piezoelectric Materials

A simple and efficient mechanochemical-induced approach for the synthesis of 1,2-diketoindolizine derivatives has been developed. BaTiO3 was used as the piezoelectric material in this transformation. This method features no usage of solvent, simple experimental operation, scalable potential, and high conversion efficiency, which make it attractive and practical.

Visible-Light-Induced Regioselective Dicarbonylation of Indolizines with Oxoaldehydes via Direct C-H Functionalization

A metal-free system for regioselective dehydrogenative cross-couplings between indolizines and oxoaldehydes catalyzed by visible light under mild conditions has been described. As an atom economical and eco-friendly protocol, the reaction proceeds in good yields using inexpensive, readily available visible-light sources and the environmentally friendly oxidant oxygen. Various valuable 1,2-dicarbonyl derivatives attached to an indolizine core were easily accessed by the direct dicarbonylation of the sp2 C-H bond.