749863-29-4

Basic information

• Product Name: methyl 5-(dimethylamino)-2-nitrobenzenecarboxylate
• Synonyms: methyl 5-(dimethylamino)-2-nitrobenzenecarboxylate;Methyl 5-(dimethylamino)-2-nitrobenzoate
• CAS NO: 749863-29-4
• Molecular Formula: C₁₀H₁₂N₂O₄
• Molecular Weight: 224.21328
• Mol File: 749863-29-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 98-100°
• Boiling Point: 368.3±32.0 °C(Predicted)
• Appearance: /
• Density: 1.265±0.06 g/cm3(Predicted)
• PKA: -0.60±0.22(Predicted)
• CAS DataBase Reference: methyl 5-(dimethylamino)-2-nitrobenzenecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 5-(dimethylamino)-2-nitrobenzenecarboxylate(749863-29-4)
• EPA Substance Registry System: methyl 5-(dimethylamino)-2-nitrobenzenecarboxylate(749863-29-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 749863-29-4(Hazardous Substances Data)

Upstream product

• 506-59-2 N,N-dimethylammonium chloride 
• 67-68-5 dimethyl sulfoxide 
• 393-85-1 methyl 5-fluoro-2-nitrobenzoate 
• 67-56-1 methanol 
• 62876-66-8 5-dimethylamino-2-nitrobenzoic acid 
• 2516-95-2 5-chloro-2-nitrobenzoic acid 

Downstream Products

• 1012869-74-7 trifluoromethanesulfonate (3-methoxycarbonyl-4-nitrophenyl)trimethylammonium 
• 749863-32-9 methyl 2-amino-5-(dimethylamino)benzoate 

Relevant articles and documents

Tuning a robust system: N,O zinc guanidine catalysts for the ROP of lactide

Non-toxic, highly active and robust complexes are the holy grail as ideal green catalysts for the polymerisation of biorenewable and biodegradable polylactide. Four new zinc guanidine complexes [ZnCl2(TMG4NMe2asme)], [ZnCl2(TMG5Clasme)], [ZnCl2(TMG5Measme)] and [ZnCl2(TMG5NMe2asme)] with different electron-donating and electron-withdrawing groups on the ligand's aromatic backbone have been synthesised. Ligands are derived from low-cost commercially available compounds and have been converted by a three- or four-step synthesis process into the desired ligand in good yields. The compounds have been fully characterised and tested in the ROP of rac-LA under industrially relevant conditions. The complexes are based on the recently published structure [ZnCl2(TMGasme)] which has shown high activity in the polymerisation of lactide at 150 °C. Different substituents in the para-position of the guanidine moiety significantly increase the polymerisation rate whereas positioning substituents in the meta-position causes no change in the reaction rate. With molecular weights over 71000 g mol-1 being achievable, the best system produces polymers for multiple industrial applications and its polymerisation rate approaches that of Sn(Oct)2. The robust systems are able to polymerise non-purified lactide. The initiation of the polymerisation is suggested to occur due to impurities in the monomer.

COMPOUNDS AND METHODS FOR 18F LABELED AGENTS

The present invention relates to novel compounds suitable for or already radiolabeled with 18F, methods of making such compounds and use of such compounds for diagnostic imaging. Such labeled compounds are characterized by Formula II, wherein the substituents G, Q, L, Y and U have the meaning as defined in the specification and claims.

PROCESS FOR PRODUCING PHENYLALANINE DERIVATIVE HAVING QUINAZOLINEDIONE SKELETON AND INTERMEDIATE FOR THE SAME

The present invention provides a method for producing a phenylalanine derivative(s) having a quinazolinedione ring of formula (5), including steps comprising of:reacting an acylphenylalanine derivative(s) of formula (1) with a carbonyl group-introducing r