749898-92-8

Basic information

• Product Name: 2-Chloro-4-(4-methylpiperazin-1-yl)pyrimidine
• Synonyms: 2-Chloro-4-(4-methylpiperazin-1-yl)pyrimidine
• CAS NO: 749898-92-8
• Molecular Formula: C₉H₁₃ClN₄
• Molecular Weight: 212.68
• Product Categories: pharmacetical
• Mol File: 749898-92-8.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 365.6°C at 760 mmHg
• Flash Point: 174.9°C
• Appearance: /
• Density: 1.242g/cm³
• Vapor Pressure: 1.56E-05mmHg at 25°C
• Refractive Index: 1.565
• CAS DataBase Reference: 2-Chloro-4-(4-methylpiperazin-1-yl)pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4-(4-methylpiperazin-1-yl)pyrimidine(749898-92-8)
• EPA Substance Registry System: 2-Chloro-4-(4-methylpiperazin-1-yl)pyrimidine(749898-92-8)

Safety Data

• Hazardous Substances Data: 749898-92-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H13ClN4/c1-13-4-6-14(7-5-13)8-2-3-11-9(10)12-8/h2-3H,4-7H2,1H3

Upstream product

• 109-01-3 1-methyl-piperazine 
• 3934-20-1 2,6-Dichloropyrimidine 

Downstream Products

• 895532-96-4 N-{6-[4-(4-Methylpiperazin-1-yl)pyrimidin-2-ylamino]benzothiazol-2-yl}benzamide 
• 895533-00-3 N-{5-[4-(4-Methylpiperazin-1-yl)pyrimidin-2-ylamino]benzothiazol-2-yl}benzamide 
• 1130756-99-8 4-(4-Methyl-piperazin-1-yl)-2-phenyl-pyrimidine 
• 1351933-80-6 2-(4-(benzyloxy)phenyl)-4-(4-methylpiperazin-1-yl)pyrimidine 
• 1620988-91-1 N-(4-chlorophenyl)-4-(4-methylpiperazin-1-yl)pyrimidin-2-amine 
• 1620988-90-0 N-(4-methoxyphenyl)-4-(4-methylpiperazin-1-yl)pyrimidin-2-amine 

Relevant articles and documents

Diaminopyrimidines, diaminopyridines and diaminopyridazines as histamine H4 receptor modulators

Previously disclosed H4 receptor modulators, the triamino substituted pyridines and pyrimidines, contain a free primary amino (-NH2) group. In this Letter we demonstrate that an exocyclic amine (NH2) is not needed to maintain affinity, and also show a significant divergence in the SAR of the pendant diamine component. These des-NH2 azacycles also show a distinct functional spectrum, that appears to be influenced by the diamine component; in the case of the 1,3-amino pyrimidines, the preferred diamine is the amino pyrrolidine instead of the more common piperazines. Finally, we introduce 3,5-diamino pyridazines as novel histamine H4 antagonists.

SAR optimization studies on a novel series of 2-anilinopyrimidines as selective inhibitors against triple-negative breast cancer cell line MDA-MB-468

Triple-negative breast cancers (TNBCs) account for approximately 15% of breast cancer cases and exhibit an aggressive clinical behavior. In this study, we designed and synthesized two series of 2-anilinopyrimidines based on the structure of our previously

BICYCLIC COMPOUND AND USE THEREOF FOR INHIBITING SUV39H2

The present invention directs to a compound represented by formula (I).