7500-76-7

Basic information

• Product Name: 4,4'-benzylidenedianisole
• Synonyms: 4,4'-benzylidenedianisole;4,4'-dimethoxytrityl cation;1,1'-Benzylidenebis(4-methoxybenzene);4,4'-Benzylidenebisanisole;Di(4-methoxyphenyl)phenylmethane
• CAS NO: 7500-76-7
• Molecular Formula: C₂₁H₂₀O₂
• Molecular Weight: 304.3823
• EINECS: 231-356-7
• Mol File: 7500-76-7.mol
• Article Data: 32

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4,4'-benzylidenedianisole(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4'-benzylidenedianisole(7500-76-7)
• EPA Substance Registry System: 4,4'-benzylidenedianisole(7500-76-7)

Safety Data

• Hazardous Substances Data: 7500-76-7(Hazardous Substances Data)

Usage

General Description

4,4'-Benzylidenedianisole, also known as oxybenzone, is an organic compound commonly used in sunscreens and other personal care products as a UV filter. It absorbs and dissipates UV radiation, providing protection against sunburn and skin damage. However, concerns have been raised about its potential hormone-disrupting effects and impact on marine ecosystems, leading to its restriction or ban in some countries. Despite its effectiveness in protecting against UV rays, 4,4'-benzylidenedianisole has come under scrutiny for its potential risks to human health and the environment, leading to ongoing debate and regulation around its use.

Upstream product

• 720-44-5 1-(4-methoxyphenyl)-1-phenylmethanol 
• 4081-02-1 4,4'-benzylidene-di-phenol 
• 56074-65-8 bis-(4-methoxy-phenyl)-phenyl-acetaldehyde 
• 120264-80-4 2,2-bis(4-methoxyphenyl)-2-phenylacetonitrile 
• 100-52-7 benzaldehyde 
• 100-66-3 methoxybenzene 
• 79-11-8 chloroacetic acid 
• 541-88-8 Chloroacetic anhydride 
• 40615-35-8 4,4'-dimethoxytrityl alcohol 
• 108-95-2 phenol 
• 6425-08-7 4,4'-(phenylmethylene)bismorpholine 
• 7334-52-3 benzaldehyde diethyldithioacetal 
• 67-56-1 methanol 
• 40615-36-9 4,4'-dimethoxytrityl chloride 

Downstream Products

• 321991-67-7 5'-O-(4,4'-dimethoxytrityl)-5-carbomethoxymethyluridine 

Relevant articles and documents

Niobium Pentachloride Mediated (Hetero)aromatic Aldehyde Friedel-Crafts Hydroxyalkylation with Arenes: An Efficient Strategy to Synthesize Triarylmethanes

Niobium pentachloride is an efficient and useful Lewis acid to conduct Friedel-Crafts hydroxyalkylation between arenes and (hetero)aromatic aldehydes, to generate triarylmethanes. This practical methodology offers several advantages, such as short reaction time, mild experimental conditions, and excellent yields.

Solventless triarylmethane synthesis via hydroxyalkylation of anisole with benzaldehyde by modified heteropoly acid on mesocellular foam silica (MCF)

Triarylmethane (TRAM) compounds have wide applications such as leuco dyes for sensing tumors and other biological activities. Hydroxyalkylation of arenes with benzaldehyde results in formation of triarylmethane compounds. In the present study, 20 (wt.%) Cs2.5H0.5PW12O40 (Cs-DTP) supported on mesocellular foam (MCF) silica was prepared, characterized and tested for its activity in hydroxyalkylation reaction of anisole with benzaldehyde. Its activity was compared with commercial catalysts like Amberlyst-15, montmorillonite clay K-10, H3PW12O40 and unsupported Cs2.5H0.5PW12O40.The prepared catalyst showed the best activity compared to others with advantage of separation of catalyst and reusability. Reaction parameters were studied in detail and kinetic study was carried out for the said reaction. 20 (wt. %) Cs-DTP/MCF was found to be the best, robust and reusable catalyst. Reaction mechanism and kinetics were also studied. The results are new.

Hydride Reduction by a Sodium Hydride-Iodide Composite

Sodium hydride (NaH) is widely used as a Br?nsted base in chemical synthesis and reacts with various Br?nsted acids, whereas it rarely behaves as a reducing reagent through delivery of the hydride to polar π electrophiles. This study presents a series of reduction reactions of nitriles, amides, and imines as enabled by NaH in the presence of LiI or NaI. This remarkably simple protocol endows NaH with unprecedented and unique hydride-donor chemical reactivity.