75007-33-9

Basic information

• Product Name: 2-(3,5-Dimethyl-1H-pyrazol-1-yl)-4-phenylthiazole
• Synonyms: 2-(3,5-Dimethyl-1H-pyrazol-1-yl)-4-phenylthiazole
• CAS NO: 75007-33-9
• Molecular Formula: C₁₄H₁₃N₃S
• Molecular Weight: 255.3381
• Mol File: 75007-33-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 453.7°Cat760mmHg
• Flash Point: 228.2°C
• Appearance: /
• Density: 1.24g/cm³
• Vapor Pressure: 2.02E-08mmHg at 25°C
• Refractive Index: 1.671
• CAS DataBase Reference: 2-(3,5-Dimethyl-1H-pyrazol-1-yl)-4-phenylthiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,5-Dimethyl-1H-pyrazol-1-yl)-4-phenylthiazole(75007-33-9)
• EPA Substance Registry System: 2-(3,5-Dimethyl-1H-pyrazol-1-yl)-4-phenylthiazole(75007-33-9)

Safety Data

• Hazardous Substances Data: 75007-33-9(Hazardous Substances Data)

Usage

Chemical class

Thiazole compounds

Structure

Contains a pyrazol ring attached to a phenyl group

Biological activities

Ability to act as a ligand for various receptors and enzymes in the body

Potential applications

Medicinal chemistry as a lead compound for the development of new drugs

Research status

Further research needed to fully understand its properties and potential uses

InChI:InChI=1/C14H13N3S/c1-10-8-11(2)17(16-10)14-15-13(9-18-14)12-6-4-3-5-7-12/h3-9H,1-2H3

Upstream product

• 1124-15-8 3,5-dimethyl-1H-pyrazole-1-carbothioamide 
• 70-11-1 α-bromoacetophenone 
• 34176-52-8 2-hydrazino-4-phenylthiazole 
• 123-54-6 acetylacetone 
• 17574-10-6 (4-phenyl-thiazol-2-yl)hydrazine hydrochloride 
• 13665-04-8 2,2-dibromoacetophenone 
• 79-19-6 thiosemicarbazide 
• 4636-16-2 iodoacetophenone 

Relevant articles and documents

Co(ii), Ni(ii) and Cu(ii) complexes with phenylthiazole and thiosemicarbazone-derived ligands: Synthesis, structure and cytotoxic effects

Complexes of Co(ii), Ni(ii) and Cu(ii) with 2-(3,5-dimethyl-1H-pyrazole-1-yl)-4-phenyl-1,3-thiazole (a) and 3,5-dimethyl-1H-pyrazole-1-carbothioamide (b) ligands were synthesized. The crystal and molecular structures of four of them were determined by the X-ray diffraction method. In the complexes with ligand a the metal atom was bound via two nitrogen atoms, whereas ligand b interacted through the nitrogen and sulfur atoms. Comparing the coordination modes observed for both studied ligands, the thiocarbamoyl sulfur atom can participate in metal binding and in bridge formation, whereas the thiazole (aromatic) sulfur atom is not involved in the coordination. This effect seems to enhance (at least partially) conformational flexibility. Hydrogen bonds played a principal role in the crystal network formation of the analyzed compounds. The cytotoxic activity of the complexes against HL-60 and NALM-6 leukemia cells and the WM-115 melanoma cell line was also measured. The copper(ii) complex with the thiosemicarbazone ligand (7b) exhibited relatively high cytotoxicity towards all tested tumor cells. The cytotoxicity of copper(ii) complexes 7b and 9b against the melanoma WM-115 cells was over three times higher than that of cisplatin. This journal is

Sodium carbonate-mediated facile synthesis of 4-substituted-2-(3,5- dimethylpyrazol-1-yl)thiazoles under solvent-free conditions

An efficient and facile synthesis of 4-substituted-2-(3,5-dimethylpyrazol- 1-yl)thiazoles 3 was achieved by grinding an equimolar mixture of -haloketones 2 with 3,5-dimethylpyrazol-1-thiocarboxamide 1 in the presence of sodium carbonate under the solvent-

β,β-Dibromoketones: A superior alternative to β-bromoketones in hantzsch thiazole synthesis

β,β-Dibromoketones (2) have been found to be a superior alternative to the conventionally used β-bromoketones (1) for performing the Hantzsch thiazole synthesis.1 These crystalline, nonlachrymatory compounds are more reactive than 1 as demonstrated by the