7501-57-7

Basic information

• Product Name: (3-methoxy-4-nitro-phenyl)-phenyl-methanone
• Synonyms: (3-methoxy-4-nitro-phenyl)-phenyl-methanone
• CAS NO: 7501-57-7
• Molecular Formula: C₁₄H₁₁NO₄
• Molecular Weight: 257.2414
• Mol File: 7501-57-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 103 °C
• Boiling Point: 438.2°Cat760mmHg
• Flash Point: 199.7°C
• Appearance: /
• Density: 1.264g/cm³
• Vapor Pressure: 7.01E-08mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: (3-methoxy-4-nitro-phenyl)-phenyl-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (3-methoxy-4-nitro-phenyl)-phenyl-methanone(7501-57-7)
• EPA Substance Registry System: (3-methoxy-4-nitro-phenyl)-phenyl-methanone(7501-57-7)

Safety Data

• Hazardous Substances Data: 7501-57-7(Hazardous Substances Data)

Usage

General Description

"(3-methoxy-4-nitro-phenyl)-phenyl-methanone" is a chemical compound with the molecular formula C14H11NO4. It is a yellow solid that is commonly used in organic synthesis and pharmaceutical research. (3-methoxy-4-nitro-phenyl)-phenyl-methanone contains a 3-methoxy-4-nitrophenyl group and a phenyl group connected by a methanone linker. It is known to have potential pharmacological activities and has been studied for its potential as an anti-inflammatory and anti-cancer agent. However, it is important to use caution when handling and working with this compound, as it may have potential hazards and risks associated with its use.

InChI:InChI=1/C14H11NO4/c1-19-13-9-11(7-8-12(13)15(17)18)14(16)10-5-3-2-4-6-10/h2-9H,1H3

Upstream product

• 654068-47-0 (R)-3-methoxy-4-nitrobenzilic acid 
• 448-19-1 4-fluoro-2-methoxy-1-nitrobenzene 
• 81036-97-7 (2S,5S)-2-tert-butyl-5-phenyl-1,3-dioxolan-4-one 
• 654068-40-3 (2S,5R)-2-tert-butyl-5-(3-methoxy-4-nitrophenyl)-5-phenyl-1,3-dioxolan-4-one 
• 91-23-6 2-Nitroanisole 
• 143064-49-7 1-(Ethoxy-phenyl-methyl)-1H-benzotriazole 
• 98-87-3 benzylidene dichloride 

Relevant articles and documents

α-Chlorobenzylation of Nitroarenes via Vicarious Nucleophilic Substitution with Benzylidene Dichloride: Umpolung of the Friedel-Crafts Reaction

Readily available α,α-dichlorotoluenes enter a vicarious nucleophilic substitution (VNS) reaction with electron-deficient arenes to give α-chlorobenzylated nitrobenzenes, as well as six- and five-membered heterocycles. Oxidation of the initially formed α-chlorobenzylic carbanions instead of protonation results in formation of diaryl ketones, providing a means for overall nucleophilic C-H benzoylation of electron-deficient aromatic rings. Alternatively, benzoylated nitroarenes can be obtained via the reaction of isolated α-chlorodiarylmethanes with sodium azide.

Mandelic Acid as Synthetic Equivalent of Benzoyl Carbanion. Synthesis of Nitrobenzophenones

Nitrobenzophenones are prepared from a mandelic acid dioxolanone. The sequence starts with the aromatic nucleophilic substitution of the enolate of the dioxolanone onto p-fluoronitrobenzenes, followed by hydrolysis of the acetal moiety and oxidative decarboxylation of the resulting α-hydroxyacids. The whole sequence involves the use of mandelic acid as synthetic equivalent of the benzoyl carbanion.