7501-65-7Relevant articles and documents
The Synthesis of Alkyl and (Hetero)aryl Sulfonamides from Sulfamoyl Inner Salts
Young, Joseph M.,Lee, Aisha G.,Chandrasekaran, Ramalakshmi Y.,Tucker, Joseph W.
, p. 8417 - 8423 (2015/09/02)
An approach to the synthesis of sulfonamides from sulfamoyl inner salts and organometallic species is presented. A range of sulfamoyl carbamates, amines, and metals are explored. Primary, secondary, and tertiary alkyl-, aryl-, and heteroaryllitihium and magnesium nucleophiles were successful. This approach yields bench-stable intermediates and avoids many of the functional group incompatibilities, regioselectivity issues, and high-energy reagents generally associated with the synthesis of sulfonamides. Additionally, the products may be purified by basic extraction or salt formation, avoiding chromatography.