75052-60-7

Basic information

• Product Name: 7H-Thiazolo[3,2-a]pyridine-6,8-dicarbonitrile, 5-amino-7-(4-chlorophenyl)-2-[(4-chlorophenyl)methylene]-2,3-dihydro-3 -oxo-
• CAS NO: 75052-60-7
• Molecular Formula: C22H12Cl2N4OS
• Molecular Weight: 451.335
• Mol File: 75052-60-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 7H-Thiazolo[3,2-a]pyridine-6,8-dicarbonitrile, 5-amino-7-(4-chlorophenyl)-2-[(4-chlorophenyl)methylene]-2,3-dihydro-3 -oxo-(CAS DataBase Reference)
• NIST Chemistry Reference: 7H-Thiazolo[3,2-a]pyridine-6,8-dicarbonitrile, 5-amino-7-(4-chlorophenyl)-2-[(4-chlorophenyl)methylene]-2,3-dihydro-3 -oxo-(75052-60-7)
• EPA Substance Registry System: 7H-Thiazolo[3,2-a]pyridine-6,8-dicarbonitrile, 5-amino-7-(4-chlorophenyl)-2-[(4-chlorophenyl)methylene]-2,3-dihydro-3 -oxo-(75052-60-7)

Safety Data

• Hazardous Substances Data: 75052-60-7(Hazardous Substances Data)

Upstream product

• 1867-38-5 4-chlorobenzylidenemalonodinitrile 
• 68-11-1 mercaptoacetic acid 
• 128061-95-0 (E)-3-(4-Chloro-phenyl)-2-{5-[1-(4-chloro-phenyl)-meth-(Z)-ylidene]-4-oxo-4,5-dihydro-thiazol-2-yl}-acrylonitrile 
• 109-77-3 malononitrile 
• 74246-64-3 2-cyanomethyl-2-thiazolin-4-one 
• 104-88-1 4-chlorobenzaldehyde 
• 2365-48-2 Methyl thioglycolate 
• 3364-82-7 2-(4-oxothiazolidine-2-ylidene)acetonitrile 
• 128798-21-0 (E)-3-(4-Chloro-phenyl)-2-(4-hydroxy-thiazol-2-yl)-acrylonitrile 
• 623-51-8 ethyl 2-sulfanylacetate 

Downstream Products

• 1350631-49-0 C₂₉H₁₆Cl₂N₆OS 
• 1350631-54-7 C₃₉H₂₃Cl₂N₇O₄S 
• 1350631-44-5 C₂₉H₁₆Cl₂N₄O₂S 

Relevant articles and documents

Synthesis of various fused heterocyclic rings from thiazolopyridine and their pharmacological and antimicrobial evaluations

Various fused-heterocyclic-derivatives containing thiazolopyridine moieties has been synthesized by allowing 5-aminothiazolo[3,2-a]pyridine derivative 1 to undergo annulations reactions with different reagents under different-reaction conditions. The biological assessment of compounds 2, 11, 14, 15, and 19 showed remarkable antimicrobial activities. In addition, selected derivatives of the products were screened for their anticancer activities against two tumor cell lines using MTT assay and the results showed that some of these compounds have potent cytotoxic effect, as concluded from their IC50 values. Meanwhile, compounds 3a, 7 have exhibited very strong potency as anticancer candidates. Thiazolopyridine structures have been confirmed as a useful lead compounds for the development of new anticancer agents. Molecular docking showed that,-some of the synthesized compounds more suitable inhibitor against-ALR2 with farther alteration in future.

One-pot synthesis of thiazolo[3,2-α]pyridine derivatives catalysed by ionic liquids

A green method for the synthesis of thiazolo[3,2-α]pyridine derivatives via the coupling of malononitrile, an aryl aldehyde and methyl thioglycolate in an ionic liquid has been developed. The advantages of this protocol are that it is non-toxic, no by-products are formed, short reaction times are required and high yields are obtained. Thiazolo [3,2-a]pyridines have important biological and medical applications.

THE REACTION OF THIOGLYCOLIC ACID WITH α,β-UNSATURATED NITRILES: A NEW ROUTE FOR THE SYNTHESIS OF THIAZOLOPYRIDINES

The reaction of cinnamonitriles with thioglycolic acid in the presence of a basic catalyst affords thiazolopyridine derivatives.