7506-36-7 Usage
General Description
2-{[(4-Ethoxyphenyl)amino]methyl}-1H-isoindole-1,3(2H)-dione is a chemical compound with a molecular formula C20H18N2O4. It is a dye intermediate used in the production of various dyes and pigments. It has a dark red to brown color and is insoluble in water. 2-{[(4-Ethoxyphenyl)amino]methyl}-1H-isoindole-1,3(2H)-dione is also used in the synthesis of pharmaceuticals and as a research tool in the study of organic chemistry. Its structure consists of an isoindole-1,3(2H)-dione core with an amino methyl group and an ethoxyphenyl group attached, making it a versatile building block for the synthesis of a variety of organic compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 7506-36-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,5,0 and 6 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 7506-36:
(6*7)+(5*5)+(4*0)+(3*6)+(2*3)+(1*6)=97
97 % 10 = 7
So 7506-36-7 is a valid CAS Registry Number.
InChI:InChI=1/C17H16N2O3/c1-2-22-13-9-7-12(8-10-13)18-11-19-16(20)14-5-3-4-6-15(14)17(19)21/h3-10,18H,2,11H2,1H3
7506-36-7Relevant articles and documents
Isoindole-1,3-dione derivatives as RSK2 inhibitors: Synthesis, molecular docking simulation and SAR analysis
Zhou, Wei,Li, Shiliang,Lu, Weiqiang,Yuan, Jun,Xu, Yufang,Li, Honglin,Huang, Jin,Zhao, Zhenjiang
supporting information, p. 292 - 296 (2016/03/01)
RSK2 (p90 ribosomal S6 kinase 2) is a serine/threonine kinase expressed in a variety of cancers. Molecular-targeted inhibition of RSK2 as a potential therapeutic strategy for human cancers has been documented. In this work, a series of isoindole-1,3-dione derivatives as novel RSK2 inhibitors were designed and synthesized from a hit discovered in our previous study. Some compounds were confirmed to be moderately potent RSK2 inhibitors with IC50 values of about 0.5 μM. Structure-activity relationship analysis and binding mode studies by molecular docking were performed.
