750649-62-8

Basic information

• Product Name: 1H-Isoindol-1-one,2,3-dihydro-4-methoxy-2-methyl-(9CI)
• Synonyms: 1H-Isoindol-1-one,2,3-dihydro-4-methoxy-2-methyl-(9CI);4-methoxy-2-methylisoindolin-1-one
• CAS NO: 750649-62-8
• Molecular Formula: C10H11NO2
• Molecular Weight: 177.202
• Product Categories: METHOXY
• Mol File: 750649-62-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Isoindol-1-one,2,3-dihydro-4-methoxy-2-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindol-1-one,2,3-dihydro-4-methoxy-2-methyl-(9CI)(750649-62-8)
• EPA Substance Registry System: 1H-Isoindol-1-one,2,3-dihydro-4-methoxy-2-methyl-(9CI)(750649-62-8)

Safety Data

• Hazardous Substances Data: 750649-62-8(Hazardous Substances Data)

Upstream product

• 724433-52-7 3-diphenylphosphinoyl-4-methoxy-2-methyl-2,3-dihydro-1H-isoindol-1-one 
• 1521-38-6 2,3-dimethoxybenzoic acid 
• 7169-06-4 2,3-dimethoxybenzoyl chloride 
• 724433-55-0 N-diphenylphosphinoylmethyl-2,3-dimethoxy-N-methylbenzamide 
• 366453-22-7 4-methoxyisoindolin-1-one 
• 74-88-4 methyl iodide 

Relevant articles and documents

MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS

Methods are provided for modulating MRGPR X4 generally, or for treating a MRGPR X4 dependent condition more specifically, by contacting the MRGPR X4 or administering to a subject in need thereof, respectively, an effective amount of a compound having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein m, n, p, t, A, B, Z, R1, R2 and R3 are as defined herein. Pharmaceutical compositions containing such compounds, as well as to compounds themselves, are also provided. The Mas-Related G-protein (MRGPR) X4 modulators, are in particular isoindolinones and isoquinolinones substituted on the carbocyclic ring. The compounds are useful to treat itch associated conditions, pain associated conditions, or an autoimmune disorder.