7508-12-5

Basic information

• Product Name: 2,3-dimethyl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one
• CAS NO: 7508-12-5
• Molecular Formula: C₁₃H₁₆O
• Molecular Weight: 188.2655
• Mol File: 7508-12-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 335°C at 760 mmHg
• Flash Point: 144.9°C
• Density: 1.028g/cm³
• Vapor Pressure: 0.000123mmHg at 25°C
• Refractive Index: 1.539
• CAS DataBase Reference: 2,3-dimethyl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dimethyl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one(7508-12-5)
• EPA Substance Registry System: 2,3-dimethyl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one(7508-12-5)

Safety Data

• Hazardous Substances Data: 7508-12-5(Hazardous Substances Data)

Usage

General Description

2,3-dimethyl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one is a chemical compound with a complex and specific structure. It is a cyclic ketone, which can also be referred to as a cyclopentenone. Its molecular formula is C15H18O, and it is an organic compound that is derived from the cyclic structure of benzene. This chemical has several applications in organic synthesis and can be used in the production of various pharmaceuticals and agrochemicals. Due to its complex structure, it requires careful handling and precise synthesis techniques. Overall, it is an important compound in the field of organic chemistry and has various industrial applications.

Upstream product

• 35872-49-2 5-(3,4-dimethyl-phenyl)-valeric acid 
• 107272-51-5 2,3-dimethyl-6,7,8,9-tetrahydro-benzocyclohepten-5-one oxime 
• 5205-39-0 ethyl glutaroyl chloride 
• 95-47-6 o-xylene 
• 7508-13-6 5-(3,4-dimethyl-phenyl)-5-oxo-valeric acid 
• 108-55-4 glutaric anhydride, 
• 504-02-9 1,3-cylohexanedione 

Downstream Products

• 7508-31-8 8,9-dimethyl-5,6-dihydro-4H-benzo[6,7]cyclohepta[1,2-b]furan-2,3-dione 
• 749900-82-1 2-(2-imino-8,9-dimethyl-1,4,5,6-tetrahydro-2H-benzo[7,8]cyclohepta[d][1,3]thiazol-1-yl)-1-phenyl-1-ethene-1-ol 
• 326805-57-6 11-(4-chlorophenyl)-2,3-dimethyl-6,7,11,12-tetrahydro-5H-benzo[3',4']cyclohepta[2',1':4,5]thieno[2,3-d]pyrimidin-12-imine 

Relevant articles and documents

Iridium/f-Amphol-catalyzed Efficient Asymmetric Hydrogenation of Benzo-fused Cyclic Ketones

Iridium/f-Amphol-catalyzed asymmetric hydrogenation of various benzo-fused five to seven-membered cyclic ketones was successfully developed, affording a series of chiral benzo-fused cyclic alcohols with excellent results (75%–99% yields, 93%–>99% ee, and TON up to 297 000). The enantioenriched products can be employed as key intermediates or motifs for the synthesis of some important biologically active compounds, such as rasagiline mesylate TVP-1012 used for the treatment of Parkinson's disease, the enantiomer of anticonvulsant drug eslicarbazepine acetate (BIA 2-093). (Figure presented.).

Three-component, one-pot synthesis of benzo[6,7]cyclohepta[1,2-b]pyridine derivatives under catalyst free conditions and evaluation of their anti-inflammatory activity

An efficient three-component protocol is described for the synthesis of benzo[6,7]cyclohepta[1,2-b]pyridine derivatives using β-chloroacroleins, 1,3-dicarbonyls and ammonium acetate under catalyst free conditions by using ethanol as reaction media. The mild reaction conditions, operational simplicity and high yields are the advantages of this protocol and the broad scope of this one-pot reaction makes this procedure promising for practical usages. All the final compounds were screened for anti-inflammatory activity. Among the compounds tested, the compounds 5a, 5b, 5c, 5d, 5f, and 5k exhibited significant inhibition of IL-1β and MCP-1 secretion as a measure of anti-inflammatory activity.

Oxidative deoximation with H2O2 and MCM-41

A simple and mild method of oxidative deoximation with 30%H 2O2 and MCM-41 is described. This method is effective for deprotection of ketones and aldehydes.