75116-78-8Relevant articles and documents
Synthesis of the precursor of anti-inflammatory agents by cross-coupling using electrogenerated highly reactive zinc
Jalil, Aishah A.,Kurono, Nobuhito,Tokuda, Masao
, p. 2681 - 2686 (2002)
Highly reactive zinc metal was readily prepared by electrolysis of a DMF solution containing naphthalene and a supporting electrolyte in a one-compartment cell fitted with a platinum cathode and a zinc anode. This reactive zinc was used for efficient transformation of ethyl 2-bromoacrylate into the corresponding organozinc compound, which was reacted with various aryl iodides in the presence of palladium catalyst to give the corresponding cross-coupling products, ethyl 2-arylpropenoates, in high yields. These cross-coupling reactions were successfully applied to a synthesis of the precursors of non-steroidal anti-inflammatory agents such as ibuprofen, naproxen, ketoprofen, loxoprofen, indoprofen, suprofen, cicloprofen, and flurbiprofen.
