7517-76-2Relevant articles and documents
Isocyanates From Primary Amines and Carbon Dioxide: 'Dehydration' of Carbamate Anions
Waldman, Thomas E.,McGhee, William D.
, p. 957 - 958 (2007/10/02)
Carbamate anions, derived from primary amines CO2 and an added base (e.g.NEt3), undergo rapid reaction with electrophilic 'dehydrating agents' (e.g.POCl3, P4O10) to give the corresponding isocyanates in excellent yields.
Process for the preparation of organic mono- and polyisocyanates
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, (2008/06/13)
A process for the preparation of organic mono- and polyisocyanates is described, in which a hydrogen chloride adduct of a trisubstituted urea is thermally decomposed to form the isocyanate. The hydrogen chloride adduct at minimum contains the stoichiometric amount of HCl, and at maximum a 10 mole-% excess. The process is carried out in a closed system at a temperature between about 80° and 180° C.; the reaction is effected either in a melt or in the presence of an inert organic solvent.