75201-83-1

Basic information

• Product Name: (1-Oxo-1,2-dihydro-isoquinolin-5-yl)-carbamic acid benzyl ester
• Synonyms: (1-Oxo-1,2-dihydro-isoquinolin-5-yl)-carbamic acid benzyl ester
• CAS NO: 75201-83-1
• Molecular Weight: 294.31
• Mol File: 75201-83-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (1-Oxo-1,2-dihydro-isoquinolin-5-yl)-carbamic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (1-Oxo-1,2-dihydro-isoquinolin-5-yl)-carbamic acid benzyl ester(75201-83-1)
• EPA Substance Registry System: (1-Oxo-1,2-dihydro-isoquinolin-5-yl)-carbamic acid benzyl ester(75201-83-1)

Safety Data

• Hazardous Substances Data: 75201-83-1(Hazardous Substances Data)

Upstream product

• 93117-08-9 5-aminoisoquinolin-1(2H)-one 
• 501-53-1 benzyl chloroformate 
• 75201-77-3 (2-Oxy-isoquinolin-5-yl)-carbamic acid benzyl ester 

Relevant articles and documents

Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors

A series of isoquinoline-1,3,4-trione derivatives were identified as novel and potent inhibitors of caspase-3 through structural modification of the original compound from high-throughput screening. Various analogues (2, 6, 9, 13, and 14) were synthesized and identified as caspase inhibitors, and the introduction of a 6-N-acyl group (compound 13) greatly improved their activity. Some of them showed low nanomolar potency against caspase-3 in vitro (for example, for 6k, IG50 = 40 nM) and significant protection against apoptosis in a model cell system. Additionally, compound 13f demonstrated a dose-dependent decrease in infarct volume in the transient MCA occlusion stroke model. The present small-molecule caspase-3 inhibitor with novel structures different from structures of known caspase inhibitors revealed a new direction for therapeutic strategies directed against diseases involving abnormally up-regulated apoptosis.