75208-40-1 Usage
Description
Quinuclidine-3-carboxylic acid, also known as 3-quinuclidinecarboxylic acid, is an organic compound with the molecular formula C10H14NO2. It is a key component in the synthesis of various pharmaceuticals due to its unique chemical structure and properties.
Uses
Used in Pharmaceutical Industry:
Quinuclidine-3-carboxylic acid is used as a building block for the development of pharmaceuticals, particularly for those targeting respiratory tract diseases. It serves as a key intermediate in the synthesis of various drug molecules.
Used in Respiratory Medicine:
Quinuclidine-3-carboxylic acid is used as a phosphodiesterase 4 (PDE4) inhibitor and muscarinic M3 receptor antagonist. These applications are crucial in the treatment of respiratory tract diseases, as they help to reduce inflammation and improve lung function by modulating the activity of specific receptors and enzymes involved in the disease process.
Check Digit Verification of cas no
The CAS Registry Mumber 75208-40-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,5,2,0 and 8 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 75208-40:
(7*7)+(6*5)+(5*2)+(4*0)+(3*8)+(2*4)+(1*0)=121
121 % 10 = 1
So 75208-40-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H13NO2/c10-8(11)7-5-9-3-1-6(7)2-4-9/h6-7H,1-5H2,(H,10,11)
75208-40-1Relevant articles and documents
(+)-3-[2-(Benzo[b]thiophen-2-yl)-2-oxoethyl]-1-azabicyclo[2.2.2]-octane as potent agonists for the α7 nicotinic acetylcholine receptor
Tatsumi, Ryo,Seio, Kohji,Fujio, Masakazu,Katayama, Jiro,Horikawa, Takashi,Hashimoto, Kenji,Tanaka, Hiroshi
, p. 3781 - 3784 (2007/10/03)
A series of 3-substituted 1-azabicyclo[2.2.2]octanes was discovered as the α7 nicotinic acetylcholine (α7) receptor agonists. It was found that (+)-3-[2-(benzo[b]thiophen-2-yl)-2-oxoethyl]-1-azabicyclo[2.2.2]octane (+)-15b has potent agonistic activity for the α7 receptor.
PURIFICATION OF 3-ETHOXYCARBONYLQUINUCLIDINE AND ITS CONVERSION TO 3-QUINUCLIDINECARBOXYLIC ACID AND 3-QUINUCLIDINYLMETHANOL
Koikov, L. N.,Lisitsa, E. A.,Alekseeva, N. A.,Turchin, K. F.,Filipenko, T. Ya.
, p. 1289 - 1292 (2007/10/02)
3-Ethoxycarbonylquinuclidine obtained by the Grob method is a mixture of 3-ethoxycarbonyl-1-azabicyclo- and, according to 13C NMR data, 5-ethoxycarbonyl-5-azatricyclo2,7>octanes (about 16:2:1). 3-Ethoxy-carbonylquinuclidine was purified by recrystallization of the hydrochloride, hydrolyzed by water to 3-quinuclidinecarboxylic acid, and reduced by LiAlH4 to 3-quinuclidinylmethanol.