752174-62-2

Basic information

• Product Name: (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoate
• Synonyms: (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic acid ethyl ester;LCZ-696 Impurity 30;LCZ-696 Impurity 37
• CAS NO: 752174-62-2
• Molecular Formula: C₂₀H₂₅NO₂
• Molecular Weight: 311.418
• EINECS: -0
• Mol File: 752174-62-2.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoate(752174-62-2)
• EPA Substance Registry System: (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoate(752174-62-2)

Safety Data

• Hazardous Substances Data: 752174-62-2(Hazardous Substances Data)

Usage

General Description

The chemical compound "(2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoate" is a specific configuration of ethyl ester derivative that contains a biphenyl group, an amino group, and a methylpentanoate group. It is a chiral compound with the stereochemistry denoted by the (2R,4S) prefix. (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoate may have potential applications in organic synthesis, pharmaceuticals, or as a research reagent. The presence of the biphenyl group suggests that it may have aromatic and hydrophobic properties, while the amino and ester groups could potentially contribute to its reactivity and functionalization. Further investigation would be needed to fully understand the properties and potential uses of this compound.

Upstream product

• 100160-75-6 methyl 4-([1,1'-biphenyl]-4-yl)-3-oxobutyrate 
• 31603-77-7 4-biphenylacetonitrile 
• 64-17-5 ethanol 
• 1038924-71-8 (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid hydrochloride 
• 1039307-95-3 (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid 
• 5728-52-9 (4-biphenylyl)acetic acid 
• 128779-47-5 (2R)-3-(biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid 
• 162972-36-3 (R)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-N-methoxy-N-metyl<1,1'-biphenyl>-4-propanamide 
• 149709-58-0 (R)-α-<<(1,1-dimethylethoxy)carbonyl>amino><1,1'-biphenyl>-4-propanal 
• 149709-59-1 (R)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpent-2-enoic acid ethyl ester 
• 149709-60-4 ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoate 

Downstream Products

• 1257265-89-6 6-amino-2-((1S,3R)-1-biphenyl-4-ylmethyl-3-carboxy-butylcarbamoyl)-pyrimidine-4-carboxylic acid 
• 1257265-90-9 4-amino-6-((1S,3R)-1-biphenyl-4-ylmethyl-3-carboxy-butylcarbamoyl)-pyrimidine-2-carboxylic acid 
• 149709-62-6 α-ethyl (αR,γS)-γ-<(3-carboxy-1-oxopropyl)amino>-α-methyl<1,1'-biphenyl>-4-pentanoate 
• 1639970-62-9 (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(2,5-dioxopyrrol-1-yl)-2-methylpentanoic acid 
• 1038924-97-8 (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(2,5-dioxopyrrol-1-yl)-2-methyl pentanoate 
• 1038924-70-7 (3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one 

Relevant articles and documents

Preparation method and application of sacubitril intermediate

The invention discloses a preparation method and application of a sacubitril intermediate. The sacubitril intermediate disclosed by the invention is obtained by taking itaconic anhydride as a raw material, performing chiral reduction, esterification, selective hydrolysis and carboxyl activation, and finally conducting coupling with 4-biphenylacetic acid. The invention also provides a method for preparing sacubitril by using the sacubitril intermediate. The preparation method provided by the invention has the advantages of easily available raw materials, simple process, economy, environmental protection and the like, and is more suitable for industrial production compared with other routes.

SACUBITRIL INTERMEDIATE AND PREPARATION METHOD THEREOF

The present invention relates to a sacubitril intermediate and a preparation method thereof. The sacubitril intermediate disclosed herein can be prepared by a deprotection reaction of a compound. In addition, the intermediate can be used as a raw material to synthesize sacubitril. The method disclosed herein has advantages of easily obtained raw materials, simple preparation process, low cost, environment friendly, and etc., which is very suitable for industrial production.

Method for preparing LCZ696 impurity reference substance

The invention provides a method for preparing an LCZ696 impurity reference substance. The method comprises the following steps: performing a reaction on (2R, 4S)-5-(biphenyl-4-yl)-4-[(t-butyloxycarboryl) amino]-2-methylpentanoic acid and thionyl chloride in ethanol so as to obtain a compound of formula I; performing a reaction on the compound of the formula I under a weak alkali condition so as to obtain a compound of formula II; performing heating reflux on succinic anhydride in isopropanol so as to obtain a compound of formula III; performing a reaction on the compound of the formula III with thionyl chloride so as to obtain a compound of formula IV; preparing the LCZ696 impurity reference substance of formula V from the compound of the formula II and the compound of the formula IV under catalysis of a strong alkali catalyst. By adopting the method provided by the invention, consumption of raw materials is reduced as a whole, the method is economic and environmental-friendly, different steps of reactions can be relatively easily implemented and controlled, meanwhile the amount of heavy metal catalysts is reduced and avoided, and the quality indexes of final products are improved.