75230-47-6

Basic information

• Product Name: N′-(1-(4-cyanophenyl)ethylidene)-4-methylbenzenesulfonohydrazide
• Synonyms: N′-(1-(4-cyanophenyl)ethylidene)-4-methylbenzenesulfonohydrazide
• CAS NO: 75230-47-6
• Molecular Weight: 313.38
• Mol File: 75230-47-6.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: N′-(1-(4-cyanophenyl)ethylidene)-4-methylbenzenesulfonohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: N′-(1-(4-cyanophenyl)ethylidene)-4-methylbenzenesulfonohydrazide(75230-47-6)
• EPA Substance Registry System: N′-(1-(4-cyanophenyl)ethylidene)-4-methylbenzenesulfonohydrazide(75230-47-6)

Safety Data

• Hazardous Substances Data: 75230-47-6(Hazardous Substances Data)

Upstream product

• 1443-80-7 4-cyanophenyl methyl ketone 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 

Downstream Products

• 75193-00-9 [(NCC₆H₄CCH₂)Co(N₄C₄₄H₂₈)] 
• 1269206-74-7 4-(1-(benzo[d]oxazol-2-yl)ethyl)benzonitrile 
• 1448251-13-5 4-(1-(2-hydroxyphenyl)vinyl)benzonitrile 

Relevant articles and documents

Copper acetoacetonate [Cu(acac)2]/BINAP-promoted Csp 3-N bond formation via reductive coupling of N-tosylhydrazones with anilines

We report the the copper(II) acetoacetonate [Cu(acac)2]/BINAP- catalyzed synthesis of arylamines from N-tosylhydrazones and anilines. A fine tuning of the reaction conditions was required to accomplish the cross-coupling successfully, including the ligands effect and the addition of small amounts of water. The characteristic feature of this protocol is its functional group compatibility and its chemoselectivity when various aminophenol derivatives were used. Taking into consideration the interest for this copper-reductive coupling in which no stoichiometric metal hydride reagent is employed, this can be considered as an alternative to the conventional reductive amination.

Aryl-Diadamantyl Phosphine Ligands in Palladium-Catalyzed Cross-Coupling Reactions: Synthesis, Structural Analysis, and Application

Synthesis, temperature-dependent NMR structure investigation and utilization of a new, stable and easily accessible aryl-diadamantylphosphine ligand family is reported. The bulky and electron-rich phosphorus center of the ligand enhances the catalytic activity of palladium in cross-coupling reactions of sterically demanding ortho-substituted aryl halides. In our study, we demonstrated the synthetic applicability of the new phosphine ligands in Buchwald-Hartwig and tosyl hydrazone coupling reactions.

Toward a Greener Barluenga-Valdés Cross-Coupling: Microwave-Promoted C-C Bond Formation with a Pd/PEG/H2O Recyclable Catalytic System

A green Barluenga-Valdés cross-coupling reaction for the synthesis of 1,1-diarylethylenes using palladium catalysis has been developed. The new catalytic system based on Pd/Xphos-SO3Na or Pd/MeDavephos-CF3SO3 in PEG/H2O under microwave irradiation was found to be the best conditions for this transformation. The recyclability of the palladium catalyst system was also studied, and it was found to be active over nine runs without significant loss in its activity.