75237-09-1

Basic information

• Product Name: ETHYL 4-(4-T-BUTYLPHENYL)-4-OXOBUTYRATE
• Synonyms: ETHYL 4-(4-T-BUTYLPHENYL)-4-OXOBUTYRATE;ETHYL 4-(4-TERT-BUTYLPHENYL)-4-OXOBUTYRATE
• CAS NO: 75237-09-1
• Molecular Formula: C₁₆H₂₂O₃
• Molecular Weight: 262.34
• Mol File: 75237-09-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 373.4°C at 760 mmHg
• Flash Point: 162.1°C
• Appearance: /
• Density: 1.02g/cm³
• Vapor Pressure: 9E-06mmHg at 25°C
• Refractive Index: 1.494
• CAS DataBase Reference: ETHYL 4-(4-T-BUTYLPHENYL)-4-OXOBUTYRATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-(4-T-BUTYLPHENYL)-4-OXOBUTYRATE(75237-09-1)
• EPA Substance Registry System: ETHYL 4-(4-T-BUTYLPHENYL)-4-OXOBUTYRATE(75237-09-1)

Safety Data

• Hazardous Substances Data: 75237-09-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H22O3/c1-5-19-15(18)11-10-14(17)12-6-8-13(9-7-12)16(2,3)4/h6-9H,5,10-11H2,1-4H3

Upstream product

• 253185-03-4 tert-butylbenzene 
• 14794-31-1 ethyl 3-(chloroformyl)propionate 
• 856062-08-3 monoethylsuccinylchloride 
• 115199-59-2 ethyl 4-(p-cyclohexylphenyl)-4-oxobutanoate 
• 35288-08-5 4-(4-tert-butylphenyl)-4-oxobutyric acid 
• 623-47-2 propynoic acid ethyl ester 
• 1073375-56-0 ethyl 4-(4-(tert-butyl)phenyl)-4-oxobut-2-enoate 
• 939-97-9 4-tert-Butylbenzaldehyde 
• 623-73-4 diazoacetic acid ethyl ester 
• 1746-23-2 4-tert-Butylstyrene 

Downstream Products

• 597571-16-9 2-(2-(2-(4-t-butylphenyl)-5-oxopyrrolidin-1-yl)ethylthio)thiazole-4-carboxylic acid ethyl ester 
• 35288-08-5 4-(4-tert-butylphenyl)-4-oxobutyric acid 
• 105393-23-5 2-(4-tert-butylphenyl)cyclopropane-1-carboxylic acid ethyl ester 

Relevant articles and documents

A process for preparing γ - ketone carbonyl compounds

The present invention discloses a gamma-ketone carbonyl compound preparation method, wherein in the presence of an oxidizing agent, a styrene compound and ethyl diazoacetate are adopted as reactants, copper or a copper compound is adopted as a catalyst, DABCO is adopted as an alkali, and a free radical reaction is performed in a polar solvent isopropyl alcohol to obtain the product gamma-ketone carbonyl compound. According to the method of the present invention, the reaction activity of the catalyst is high, the reaction conditions are mild, the substrate application range is wide, the post-treatment is convenient, the yield of the target product is high, the preparation process is simple, and the sources of the used raw materials are wide.

Design and synthesis of novel antimicrobials with activity against Gram-positive bacteria and mycobacterial species, including M. tuberculosis

The alarming increase in bacterial resistance over the last decade along with a dramatic decrease in new treatments for infections has led to problems in the healthcare industry. Tuberculosis (TB) is caused mainly by Mycobacterium tuberculosis which is responsible for 1.4 million deaths per year. A world-wide threat with HIV co-infected with multi and extensively drug-resistant strains of TB has emerged. In this regard, herein, novel acrylic acid ethyl ester derivatives were synthesized in simple, efficient routes and evaluated as potential agents against several Mycobacterium species. These were synthesized via a stereospecific process for structure activity relationship (SAR) studies. Minimum inhibitory concentration (MIC) assays indicated that esters 12, 13, and 20 exhibited greater in vitro activity against Mycobacterium smegmatis than rifampin, one of the current, first-line anti-mycobacterial chemotherapeutic agents. Based on these studies the acrylic ester 20 has been developed as a potential lead compound which was found to have an MIC value of 0.4 μg/mL against Mycobacterium tuberculosis. The SAR and biological activity of this series is presented; a Michael-acceptor mechanism appears to be important for potent activity of this series of analogs.

Phosphonic acid compounds, their production and use

The present invention relates to a compound of the general formula (I): STR1 wherein ring A is a benzene ring that may be substituted; Y is a divalent group as a constituent member of ring B forming a 5- to 8-membered ring; Q1 is a group of the formula --X--P(O)(OR1)(OR2) wherein X is a bond or a divalent group; R1 and R2, identical or different, are hydrogen or a lower alkyl, or may be combined together to form a ring; Q2 is hydrogen, a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; and the group of the formula --CON(Q1)(Q2) is connected to the a- or b-position carbon atom, or a salt thereof, which is useful as prophylactic and therapeutic agents of various metabolic bone diseases such as osteoporosis.