7527-91-5 Usage
Originator
Aminacrine
hexylresorcinate
,ZYF Pharm
Uses
Antifungal.
Manufacturing Process
4-Hexylresorcinol 194.0 g is added to a solution composed of 56.1 g
potassium hydroxide in 1.5 L of water with stirring, and the mixture heated to
about 40°C to effect complete solution. The pH of this solution is 12. A second
solution of 9-aminoacridine hydrochloride is prepared as follows: 2 L of water
containing 83 ml of concentrated hydrochloric acid are heated with stirring to
about 80°C. Slowly 194.0 g of 9-aminoacridine are added. Heating is
continued until a clear solution is obtained. About 2 ml of additional
concentrated hydrochloric acid are added in small increments until the solution
is slightly acid (pH of about 6). The 4-hexyl resorcinol solution is now slowly
added under rapid agitation to the 9-aminoacridine hydrochloride solution. A
copious precipitate is formed which, upon :stirring and continued addition of
the 4-hexylresorcinol solution, becomes a creamy yellow slurry. At the end of
the addition, the pH is 7-8 (indicator paper). The slurry is stirred while heated
for an additional 15 min and then rapidly filtered on a 15 cm Buchner funnel.
The product thus obtained is washed thoroughly, using about 1 L of cold
water, to give a very pale yellow color in the last wash. The compound is then
pressed dry and then oven-dried for 2-3 h at 50°C. The resultant product, 9-
aminoacridine 4-hexyl resorcinolate, has a melting point of 189°-190°C.
Brand name
Akrinol (Schering).
Therapeutic Function
Antifungal, Anthelmintic
Check Digit Verification of cas no
The CAS Registry Mumber 7527-91-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,5,2 and 7 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 7527-91:
(6*7)+(5*5)+(4*2)+(3*7)+(2*9)+(1*1)=115
115 % 10 = 5
So 7527-91-5 is a valid CAS Registry Number.
InChI:InChI=1/C13H10N2.C12H18O2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13;1-2-3-4-5-6-10-7-8-11(13)9-12(10)14/h1-8H,(H2,14,15);7-9,13-14H,2-6H2,1H3
