7528-00-9
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Basic information
- Product Name: Dextroamphetamine phosphate
- Synonyms: Dextroamphetamine phosphate;Dextroamphetamine phosphate [usp xx]
- CAS NO:7528-00-9
- Molecular Formula: C9H16NO4P
- Molecular Weight: 233.201401
- EINECS: N/A
- Product Categories: N/A
- Mol File: 7528-00-9.mol
- Article Data: 0
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 467.2°C at 760 mmHg
- Flash Point: 236.4°C
- Appearance: /
- Density: N/A
- Vapor Pressure: 1.57E-09mmHg at 25°C
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: Dextroamphetamine phosphate(CAS DataBase Reference)
- NIST Chemistry Reference: Dextroamphetamine phosphate(7528-00-9)
- EPA Substance Registry System: Dextroamphetamine phosphate(7528-00-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 7528-00-9(Hazardous Substances Data)
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7528-00-9 Usage
General Description
Dextroamphetamine, (+)-(S)-methylphenethylamine, formssalts with sulfuric acid (Dexedrine) and with phosphoric acids.The phosphate is the more water-soluble salt and is preferredif parenteral administration is required. The dextrorotatoryisomer has the (S) configuration and fewer cardiovascular effectsthan the levorotatory (R)-isomer. Additionally, it may beup to 10 times as potent as the (R)-isomer as an alerting agentand about twice as potent a psychotomimetic agent. Althoughit is a more potent psychotomimetic agent than the (R)-isomer,it has a better ratio of alerting to psychotomimetic effects.The major mode of action of dextroamphetamine is releaseof NE from the mobile pool of the nerve terminal. Othermechanisms, such as inhibition of uptake, may make a smallcontribution to the overall effects. The alerting actions relateto increased NE available to interact with postsynaptic receptors(α1). Central β-receptor activation has classically beenconsidered the basis for most of the anorexiant effect.Clinical Use
Dextroamphetamine phosphate is a strongly basic amine, with valuesfrom 9.77 to 9.94 reported. Absorption from the gastrointestinaltract occurs as the lipid-soluble amine. The drug is not extensively protein bound. Varying amounts ofthe drug are excreted intact under ordinary conditions.Check Digit Verification of cas no
The CAS Registry Mumber 7528-00-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,5,2 and 8 respectively; the second part has 2 digits, 0 and 0 respectively.Calculate Digit Verification of CAS Registry Number 7528-00:
(6*7)+(5*5)+(4*2)+(3*8)+(2*0)+(1*0)=99
99 % 10 = 9
So 7528-00-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H13N.H3O4P/c1-8(10)7-9-5-3-2-4-6-9;1-5(2,3)4/h2-6,8H,7,10H2,1H3;(H3,1,2,3,4)/t8-;/m0./s1
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Dextroamphetamine phosphate
