75290-49-2Relevant articles and documents
Aromatic fluorination with xenon difluoride: L-3,4-dihydroxy-6-fluoro-phenylalanine
Firnau, Gunter,Chirakal, Raman,Sood, Sudesh,Garnett, Stephen
, p. 1449 - 1450 (2007/10/02)
L-3-Methoxy-4-hydroxyphenylalanine was fluorinated directly with XeF2 in CH2Cl2 at -60 deg C in vacuo.After hydrolysis with 48percent aqueous HBr, L-6-fluorodopa was obtained.The yield, based on XeF2, was 25percent.This reaction might be applied when chiral biomolecules are to be tagged with fluorine-18.