753019-89-5

Basic information

• Product Name: 1H-Imidazole-5-carboxaldehyde, 1-methyl-2-[[(4-nitrophenyl)methyl]thio]-
• CAS NO: 753019-89-5
• Molecular Formula: C12H11N3O3S
• Molecular Weight: 277.304
• Mol File: 753019-89-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Imidazole-5-carboxaldehyde, 1-methyl-2-[[(4-nitrophenyl)methyl]thio]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole-5-carboxaldehyde, 1-methyl-2-[[(4-nitrophenyl)methyl]thio]-(753019-89-5)
• EPA Substance Registry System: 1H-Imidazole-5-carboxaldehyde, 1-methyl-2-[[(4-nitrophenyl)methyl]thio]-(753019-89-5)

Safety Data

• Hazardous Substances Data: 753019-89-5(Hazardous Substances Data)

Upstream product

• 478031-87-7 5-hydroxymethyl-1-methyl-2-(p-nitrobenzyl)thioimidazole 
• 143122-18-3 5-hydroxymethyl-2-mercapto-1-methyl-1H-imidazole 
• 100-11-8 1-bromomethyl-4-nitro-benzene 

Relevant articles and documents

Synthesis and calcium channel blocker activity of alkyl 1,4-dihydro-2,6-dimethyl-4-nitrobenzyl thioimidazolyl-3,5-pyridinedicarboxylates

New alkyl ester analogues of nifedipine, in which the orthonitrophenyl group of position 4 is replaced by 1-methyl 2-(p-nitrobenzyl)thio-5-imidazolyl substituent, were synthesized and evaluated as calcium-channel antagonists using the high K+ contraction of guinea-pig ileal longitudinal smooth muscle. The results for the symmetrical esters showed that increasing the length of methylen chain in C3 and C5 ester substituents decreased activity. When the presence of bulky lipophilic esters increased activity. In ztnsymmetrical diester series, the results showed when R1 is a small substituent (R1=Me), increasing of the lipophilic property in R2 substituent increased the activity if this high lipophilicity don't accompany with steric hinderance. Our results demonstrate that the most active compound was diphenyl ester derivative and it was almost seven times more active than the reference drug nifedipine.