75322-50-8

Basic information

• Product Name: N-(p-tolyl)pyrazine-2-carboxamide
• Synonyms: N-(p-tolyl)pyrazine-2-carboxamide
• CAS NO: 75322-50-8
• Molecular Weight: 213.239
• Mol File: 75322-50-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-(p-tolyl)pyrazine-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(p-tolyl)pyrazine-2-carboxamide(75322-50-8)
• EPA Substance Registry System: N-(p-tolyl)pyrazine-2-carboxamide(75322-50-8)

Safety Data

• Hazardous Substances Data: 75322-50-8(Hazardous Substances Data)

Upstream product

• 106-49-0 p-toluidine 
• 306990-94-3 (1H-benzo[d][1,2,3]triazol-1-yl)(pyrazin-2-yl)methanone 
• 98-97-5 2-pyrazylcarboxylic acid 
• 19847-10-0 pyrazinoyl chloride 
• 768-05-8 pyrazine-2-carbohydrazide 
• 75322-66-6 pyrazine-2-carbonyl azide 

Relevant articles and documents

An Efficient Greener Approach for N-acylation of Amines in Water Using Benzotriazole Chemistry

A straightforward, mild and cost-efficient synthesis of various arylamides in water was accomplished using versatile benzotriazole chemistry. Acylation of various amines was achieved in water at room temperature as well as under microwave irradiation. The developed protocol unfolds the synthesis of amino acid aryl amides, drug conjugates and benzimidazoles. The environmentally friendly synthesis, short reaction time, simple workup, high yields, mild conditions and free of racemization are the key advantages of this protocol.

Synthesis and antimycobacterial evaluation of substituted pyrazinecarboxamides

Unsubstituted, halogenated and/or alkylated pyrazine-2-carboxylic acid amides connected via -CONH- bridge with substituted anilines were synthesized using currently known synthetic pathways. The synthetic approach, analytical, spectroscopic, lipophilicity and biological data of 20 newly synthesized compounds are presented. Structure-activity relationships among the chemical structures, the antimycobacterial, antifungal, photosynthesis inhibiting and antialgal activity of the evaluated substituted N-phenylpyrazine-2-carboxamides are discussed. 5-tert-Butyl-6-chloro-N-(3-trifluoromethylphenyl)pyrazine-2-carboxamide (19) has shown the highest activity against Mycobacterium tuberculosis H37Rv (MIC = 3.13 μg/mL). The highest antifungal effect against Trichophyton mentagrophytes, the most susceptible fungal strain tested, was found for N-(3-trifluoromethylphenyl)pyrazine-2-carboxamide (14, MIC = 62.5 μmol/mL). The highest reduction of chlorophyll content in Chlorella vulgaris was found for pyrazine-2-carboxylic acid (3-trifluoromethylphenyl)amide (9, IC50 = 12.1 μmol/L).