7533-07-5

Basic information

• Product Name: 2-ACETYL-4-METHYLTHIAZOLE, 97%
• Synonyms: Ethanone, 1-(4-methyl-2-thiazolyl)-;1-(4-methyl-1,3-thiazol-2-yl)ethanone
• CAS NO: 7533-07-5
• Molecular Formula: C₆H₇NOS
• Molecular Weight: 141.19
• EINECS: 616-211-1
• Product Categories: Heterocyclic Compounds;Building Blocks;C3 to C7;Chemical Synthesis;Heterocyclic Building Blocks;Thiazoles
• Mol File: 7533-07-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 34-38 °C(lit.)
• Boiling Point: 233.9°C at 760 mmHg
• Flash Point: 90 °C
• Appearance: /
• Density: 1.177g/cm³
• Vapor Pressure: 0.0544mmHg at 25°C
• Refractive Index: 1.539
• CAS DataBase Reference: 2-ACETYL-4-METHYLTHIAZOLE, 97%(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ACETYL-4-METHYLTHIAZOLE, 97%(7533-07-5)
• EPA Substance Registry System: 2-ACETYL-4-METHYLTHIAZOLE, 97%(7533-07-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 26-36/37
• WGK Germany: 3
• Hazardous Substances Data: 7533-07-5(Hazardous Substances Data)

Usage

General Description

2-Acetyl-4-methylthiazole, 97% is a chemical compound with a purity of 97%. It is an organic compound with the molecular formula C7H9NOS and a molecular weight of 155.22 g/mol. 2-ACETYL-4-METHYLTHIAZOLE, 97% is commonly used in the flavor and fragrance industry, where it is used to add a savory, meaty, and roasted note to food products. It has a characteristic odor described as popcorn, roasted, and nutty. In addition to its use in the food industry, 2-Acetyl-4-methylthiazole is also used in the production of pharmaceuticals and as a research chemical in various scientific studies.

InChI:InChI=1/C6H7NOS/c1-4-3-9-6(7-4)5(2)8/h3H,1-2H3

Upstream product

• 693-95-8 4-Methylthiazole 
• 925-90-6 ethylmagnesium bromide 
• 142731-30-4 4-formyl-2,5-dimethyl-1,4-thiazine 
• 100675-54-5 2-hydroxy-4-formyl-2,5-dimethyl-2,3-dihydro-1,4-thiazine 
• 142941-95-5 3-Acetonyl-4-methyl-1,3-thiazolium chloride 
• 141-78-6 ethyl acetate 
• 78191-00-1 N-Methoxy-N-methylacetamide 

Downstream Products

• 15679-12-6 2-ethyl-4-methyl-1,3-thiazole 
• 1242535-46-1 2-(N-benzylmethyl)aminoethyl-4-methyl-2-thiazolylketone 
• 1242535-42-7 2-(N-benzylisopropyl)aminoethyl-4-methyl-2-thiazolylketone 
• 7531-83-1 2-bromo-1-(4-methyl-thiazol-2-yl)-ethanone 
• 855628-40-9 2-[1-(hydroxyimino)ethyl]-4-methyl-thiazole 
• 855628-40-9 2-[1-(hydroxyimino)ethyl]-4-methyl-thiazole 

Relevant articles and documents

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Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK)

A series of SYK inhibitors based on the phenylamino pyrimidine thiazole lead 4 were prepared and evaluated for biological activity. Lead optimization provided compounds with nanomolar Ki's against SYK and potent inhibition in mast cell degranulation assays.

Reactions of 2-acylthiazolium salts with N-arylhydroxylamines

2-Acylthiazolium salts, easily obtained by alkylation of the corresponding 2-acylthiazoles with methyl triflate, react with N- arylhydroxylamines to furnish the O-acyl derivatives of relevance in the induction of cancer by aromatic mines.