75351-36-9

Basic information

• Product Name: R-1-(4-Methylbenzenesulfonate)-1,3-Butanediol
• Synonyms: R-1-(4-Methylbenzenesulfonate)-1,3-Butanediol
• CAS NO: 75351-36-9
• Molecular Formula: C₁₁H₁₆O₄S
• Molecular Weight: 244.30734
• Mol File: 75351-36-9.mol
• Article Data: 28

Chemical Properties

• Appearance: /
• CAS DataBase Reference: R-1-(4-Methylbenzenesulfonate)-1,3-Butanediol(CAS DataBase Reference)
• NIST Chemistry Reference: R-1-(4-Methylbenzenesulfonate)-1,3-Butanediol(75351-36-9)
• EPA Substance Registry System: R-1-(4-Methylbenzenesulfonate)-1,3-Butanediol(75351-36-9)

Safety Data

• Hazardous Substances Data: 75351-36-9(Hazardous Substances Data)

Upstream product

• 20585-18-6 methyl 4,6-dideoxy-α-D-glucopyranoside 
• 98-59-9 p-toluenesulfonyl chloride 
• 6290-03-5 (R)-butane-1,3-diol 
• 1312789-89-1 (3R)-3-acetoxybutyl 4-methylbenzenesulfonate 

Downstream Products

• 58917-25-2 (R)-5-methyl-2-oxotetrahydrofuran 
• 81244-76-0 (R)-(-)-2-Methyloxetane 
• 109613-35-6 (R)-3-[(tert-butyldimethylsilyl)oxy]butane-1-para-toluene sulfonate 
• 946133-90-0 (3R)-1-p-toluenesulfonyloxy-3-triethylsilyloxy-butane 
• 1215219-59-2 (R)-1-(phenylselanyl)-3-butanol 
• 1215219-60-5 (R)-1-(phenyltellanyl)-3-butanol 
• 134641-08-0 (R)-4-(phenylthio)-2-butanol 
• 610318-98-4 C₂₆H₂₇ClF₃NO 
• 1193686-56-4 C₁₃H₁₈O₄ 
• 1310533-97-1 (R)-1-(3-hydroxybutyl)-3-mesityl-1H-imidazol-3-ium 4-methylbenzenesulfonate 
• 1294453-54-5 (2R)-4-(4-bromo-3,5-dimethylphenoxy)butan-2-ol 
• 1208313-97-6 (R)-3-hydroxybutyrate (R)-1,3-butanediol monoester 

Relevant articles and documents

Preparation method of (R)-3-hydroxybutyryl-(R)-3-hydroxybutyrate

The invention discloses a preparation method of (R)-3-hydroxybutyryl-(R)-3-hydroxybutyrate. The preparation method comprises the following steps: (1) subjecting a compound (III) to reacting with paratoluensulfonyl chloride in a first solvent in the presence of alkali to obtain a compound (II); and (2) subjecting the compound (II) to reacting with (R)-3-hydroxybutyrate in a second solvent, or subjecting the compound (II) to reacting with (R)-3-hydroxybutyric acid in the presence of alkali. According to the invention, a route is simple, protection/deprotection reaction is avoided, the product can be obtained through two-step reaction from easily available raw materials, total yield is larger than or equal to 70%, and the purity of the product is larger than or equal to 95% without refining; and the method has the advantages of mild process conditions, no need for special equipment, low cost and suitability for industrial amplification, and related reagents and solvents are cheap and easy to obtain.

SUBSTITUTED BENZIMIDAZOLONES AS ANTI-CANCER AGENTS

The present invention relates to compounds of Formula I that function as inhibitors of BCL6 (B-cell lymphoma 6) activity: Formula (I) wherein X, R1, R2, and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which BCL6activity is implicated.

2 Tyrosine kinase mediated signal transduction inhibitors

Disclosed herein are compounds of Formula (), and pharmaceutically acceptable salts thereof, wherein R, R, R, R, R, X, X, X, X, X, and n are as defined herein, pharmaceutical compositions comprising same, and methods of preparation and use.